Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we show in human tissues and AD-model rats that bloodborne islet amyloid polypeptide (amylin) secreted from the pancreas perturbs c...

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Detalles Bibliográficos
Autores principales: Verma, Nirmal, Velmurugan, Gopal Viswanathan, Winford, Edric, Coburn, Han, Kotiya, Deepak, Leibold, Noah, Radulescu, Laura, Despa, Sanda, Chen, Kuey C., Van Eldik, Linda J., Nelson, Peter T., Wilcock, Donna M., Jicha, Gregory A., Stowe, Ann M., Goldstein, Larry B., Powel, David K., Walton, Jeffrey H., Navedo, Manuel F., Nystoriak, Matthew A., Murray, Andrew J., Biessels, Geert Jan, Troakes, Claire, Zetterberg, Henrik, Hardy, John, Lashley, Tammaryn, Despa, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810597/
https://www.ncbi.nlm.nih.gov/pubmed/36596993
http://dx.doi.org/10.1038/s42003-022-04398-2

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