Cargando…

Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis

The aim of this study was to evaluate the efficacy of mesenchymal stem cells (MSCs) in the regeneration of periodontal bone defects in animal models. A systematic review and meta-analysis were conducted following the PRISMA guidelines, and the study was recorded in PROSPERO under reference number CD...

Descripción completa

Detalles Bibliográficos
Autores principales: Chauca-Bajaña, Luis, Velasquez-Ron, Byron, Tomás-Carmona, Inmaculada, Camacho-Alonso, Fabio, Pérez-Jardón, Alba, Pérez‐Sayáns, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810679/
https://www.ncbi.nlm.nih.gov/pubmed/35788845
http://dx.doi.org/10.1007/s10266-022-00725-5
_version_ 1784863360084344832
author Chauca-Bajaña, Luis
Velasquez-Ron, Byron
Tomás-Carmona, Inmaculada
Camacho-Alonso, Fabio
Pérez-Jardón, Alba
Pérez‐Sayáns, Mario
author_facet Chauca-Bajaña, Luis
Velasquez-Ron, Byron
Tomás-Carmona, Inmaculada
Camacho-Alonso, Fabio
Pérez-Jardón, Alba
Pérez‐Sayáns, Mario
author_sort Chauca-Bajaña, Luis
collection PubMed
description The aim of this study was to evaluate the efficacy of mesenchymal stem cells (MSCs) in the regeneration of periodontal bone defects in animal models. A systematic review and meta-analysis were conducted following the PRISMA guidelines, and the study was recorded in PROSPERO under reference number CDR42021247462. The PICO question was: is periodontal regeneration (cementum, periodontal ligament and alveolar bone) with MSCs more effective than other techniques? Three groups were considered: Group 1: MSCs alone or mixed with regenerative materials. Group 2: only regenerative materials. Group 3: no regenerative material nor MSCs. The search was conducted using MeSH with a total of 18 articles for qualitative analysis and 5 for quantitative analysis. For the meta-analysis, a modification of the effect size algorithm was developed, which considered a comparison of means between treatments using the Student's t sample distribution. When comparing the effect size between Group 1 and Group 2, the effect size for the new cementum was 2.83 mm with an estimated confidence interval of 95% (CI 95%) between 0.48 and 5.17 mm. When considering the fit to a random-effects model, the combined variance (τ(2)) was 6.1573 mm, with a standard deviation (SD) of 5.6008 mm and a percentage of total heterogeneity I(2) of 92.33% (p < 0.0001). For new bone, the effect size was 0.88 mm, CI 95% − 0.25 to 2.01 mm, τ(2) = 1.3108 mm (SD = 1.2021 mm) and I(2) = 80.46%, p = 0.0004). With regard to the new periodontal ligament, it was not possible for the meta-analysis to be performed. MSCs have a greater capacity for tissue regeneration in root cementum than in alveolar bone compared to other regenerative materials.
format Online
Article
Text
id pubmed-9810679
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Nature Singapore
record_format MEDLINE/PubMed
spelling pubmed-98106792023-01-05 Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis Chauca-Bajaña, Luis Velasquez-Ron, Byron Tomás-Carmona, Inmaculada Camacho-Alonso, Fabio Pérez-Jardón, Alba Pérez‐Sayáns, Mario Odontology Original Article The aim of this study was to evaluate the efficacy of mesenchymal stem cells (MSCs) in the regeneration of periodontal bone defects in animal models. A systematic review and meta-analysis were conducted following the PRISMA guidelines, and the study was recorded in PROSPERO under reference number CDR42021247462. The PICO question was: is periodontal regeneration (cementum, periodontal ligament and alveolar bone) with MSCs more effective than other techniques? Three groups were considered: Group 1: MSCs alone or mixed with regenerative materials. Group 2: only regenerative materials. Group 3: no regenerative material nor MSCs. The search was conducted using MeSH with a total of 18 articles for qualitative analysis and 5 for quantitative analysis. For the meta-analysis, a modification of the effect size algorithm was developed, which considered a comparison of means between treatments using the Student's t sample distribution. When comparing the effect size between Group 1 and Group 2, the effect size for the new cementum was 2.83 mm with an estimated confidence interval of 95% (CI 95%) between 0.48 and 5.17 mm. When considering the fit to a random-effects model, the combined variance (τ(2)) was 6.1573 mm, with a standard deviation (SD) of 5.6008 mm and a percentage of total heterogeneity I(2) of 92.33% (p < 0.0001). For new bone, the effect size was 0.88 mm, CI 95% − 0.25 to 2.01 mm, τ(2) = 1.3108 mm (SD = 1.2021 mm) and I(2) = 80.46%, p = 0.0004). With regard to the new periodontal ligament, it was not possible for the meta-analysis to be performed. MSCs have a greater capacity for tissue regeneration in root cementum than in alveolar bone compared to other regenerative materials. Springer Nature Singapore 2022-07-05 2023 /pmc/articles/PMC9810679/ /pubmed/35788845 http://dx.doi.org/10.1007/s10266-022-00725-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Chauca-Bajaña, Luis
Velasquez-Ron, Byron
Tomás-Carmona, Inmaculada
Camacho-Alonso, Fabio
Pérez-Jardón, Alba
Pérez‐Sayáns, Mario
Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis
title Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis
title_full Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis
title_fullStr Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis
title_full_unstemmed Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis
title_short Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis
title_sort regeneration of periodontal bone defects with mesenchymal stem cells in animal models. systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810679/
https://www.ncbi.nlm.nih.gov/pubmed/35788845
http://dx.doi.org/10.1007/s10266-022-00725-5
work_keys_str_mv AT chaucabajanaluis regenerationofperiodontalbonedefectswithmesenchymalstemcellsinanimalmodelssystematicreviewandmetaanalysis
AT velasquezronbyron regenerationofperiodontalbonedefectswithmesenchymalstemcellsinanimalmodelssystematicreviewandmetaanalysis
AT tomascarmonainmaculada regenerationofperiodontalbonedefectswithmesenchymalstemcellsinanimalmodelssystematicreviewandmetaanalysis
AT camachoalonsofabio regenerationofperiodontalbonedefectswithmesenchymalstemcellsinanimalmodelssystematicreviewandmetaanalysis
AT perezjardonalba regenerationofperiodontalbonedefectswithmesenchymalstemcellsinanimalmodelssystematicreviewandmetaanalysis
AT perezsayansmario regenerationofperiodontalbonedefectswithmesenchymalstemcellsinanimalmodelssystematicreviewandmetaanalysis