The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the major cellular component. However, the tissue(s) of origin for CAFs remains controversial. Here we determine the tissue o...

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Detalles Bibliográficos
Autores principales: Han, Lu, Wu, Yongxia, Fang, Kun, Sweeney, Sean, Roesner, Ulyss K., Parrish, Melodie, Patel, Khushbu, Walter, Tom, Piermattei, Julia, Trimboli, Anthony, Lefler, Julia, Timmers, Cynthia D., Yu, Xue-Zhong, Jin, Victor X., Zimmermann, Michael T., Mathison, Angela J., Urrutia, Raul, Ostrowski, Michael C., Leone, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810714/
https://www.ncbi.nlm.nih.gov/pubmed/36596776
http://dx.doi.org/10.1038/s41467-022-34464-6

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