Cargando…

Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation

Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival. Treatments with IL-1RN and th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villatoro, Alicia, Cuminetti, Vincent, Bernal, Aurora, Torroja, Carlos, Cossío, Itziar, Benguría, Alberto, Ferré, Marc, Konieczny, Joanna, Vázquez, Enrique, Rubio, Andrea, Utnes, Peter, Tello, Almudena, You, Xiaona, Fenton, Christopher G., Paulssen, Ruth H., Zhang, Jing, Sánchez-Cabo, Fátima, Dopazo, Ana, Vik, Anders, Anderssen, Endre, Hidalgo, Andrés, Arranz, Lorena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810723/ https://www.ncbi.nlm.nih.gov/pubmed/36596811 http://dx.doi.org/10.1038/s41467-022-35700-9

Ejemplares similares

Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
por: Villatoro, Alicia, et al.
Publicado: (2023)

Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia
por: Villatoro, Alicia, et al.
Publicado: (2020)

Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis
por: Singh, Amrinder, et al.
Publicado: (2022)

Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model
por: Singh, Amrinder, et al.
Publicado: (2021)

Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction
por: Verboon, Jeffrey M., et al.
Publicado: (2020)

DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis
por: Taman, Hagar, et al.
Publicado: (2021)

Transcriptomic Landscape of Treatment—Naïve Ulcerative Colitis
por: Taman, Hagar, et al.
Publicado: (2018)

Genome-wide DNA Methylation in Treatment-naïve Ulcerative Colitis
por: Taman, Hagar, et al.
Publicado: (2018)

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression
por: Klein, Claudius, et al.
Publicado: (2016)

Single cell clonal analysis identifies an AID‐dependent pathway of plasma cell differentiation
por: Gómez‐Escolar, Carmen, et al.
Publicado: (2022)

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
por: Thiel, V N, et al.
Publicado: (2017)

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
por: Tripodo, Claudio, et al.
Publicado: (2022)

Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
por: Gundersen, Mona Dixon, et al.
Publicado: (2019)

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
por: Boldin, Mark P., et al.
Publicado: (2011)

Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
por: Ng, Ashley P., et al.
Publicado: (2015)

Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche
por: Cuminetti, Vincent, et al.
Publicado: (2019)

Dnmt3a Regulates Myeloproliferation and Liver-Specific Expansion of Hematopoietic Stem and Progenitor Cells
por: Guryanova, Olga A., et al.
Publicado: (2015)

Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation
por: Hamarsheh, Shaima’a, et al.
Publicado: (2020)

A Knock-In Npm1 Mutation in Mice Results in Myeloproliferation and Implies a Perturbation in Hematopoietic Microenvironment
por: Chou, Shiu-Huey, et al.
Publicado: (2012)

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation
por: Mead, Adam J., et al.
Publicado: (2017)

Associations of breast cancer related exposures and gene expression profiles in normal breast tissue—The Norwegian Women and Cancer normal breast tissue study
por: Krum‐Hansen, Sanda, et al.
Publicado: (2023)

A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals
por: Nakagawa, Masahiro Marshall, et al.
Publicado: (2019)

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets
por: Álvarez-Prado, Ángel F., et al.
Publicado: (2018)

Corrigendum: Digitaldlsorter: Deep-Learning on scRNA-Seq to Deconvolute Gene Expression Data
por: Torroja, Carlos, et al.
Publicado: (2020)

Digitaldlsorter: Deep-Learning on scRNA-Seq to Deconvolute Gene Expression Data
por: Torroja, Carlos, et al.
Publicado: (2019)

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing
por: Aitken, Marisa J L, et al.
Publicado: (2022)

Biallelic deleterious germline SH2B3 variants cause a novel syndrome of myeloproliferation and multi‐organ autoimmunity
por: Blombery, Piers, et al.
Publicado: (2023)

The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function
por: Isern, Joan, et al.
Publicado: (2014)

Nestin-expressing progenitor cells: function, identity and therapeutic implications
por: Bernal, Aurora, et al.
Publicado: (2018)

ATtRACT—a database of RNA-binding proteins and associated motifs
por: Giudice, Girolamo, et al.
Publicado: (2016)

Updates on Old and Weary Haematopoiesis
por: Konieczny, Joanna, et al.
Publicado: (2018)

Incongruence between transcriptional and vascular pathophysiological cell states
por: Fernández-Chacón, Macarena, et al.
Publicado: (2023)

Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis
por: Ray, Mithlesh Kumar, et al.
Publicado: (2022)

Detection and discrimination of diffractive events with ALICE-LHC at CERN
por: Villatoro Tello, Abraham
Publicado: (2021)

Differences in Gene Expression between First and Third Trimester Human Placenta: A Microarray Study
por: Sitras, Vasilis, et al.
Publicado: (2012)

Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling
por: Bhardwaj, Deepshikha, et al.
Publicado: (2013)

Methylation-Regulated Long Non-Coding RNA Expression in Ulcerative Colitis
por: Fenton, Christopher G., et al.
Publicado: (2023)

A framework for significance analysis of gene expression data using dimension reduction methods
por: Gidskehaug, Lars, et al.
Publicado: (2007)

Transcriptional Signatures That Define Ulcerative Colitis in Remission
por: Fenton, Christopher G, et al.
Publicado: (2020)

Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis
por: Meng, Wei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t61dumicdn25hqacj73tohmkkf