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Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study
INTRODUCTION: Schizophrenia (SZ) is a severe chronic mental disorder with increased risk of hepatitis B virus (HBV) infection, which is incurable currently and induces various negative emotions and psychological pressures in patients to exacerbate mental disorders. To facilitate the therapeutic desi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810819/ https://www.ncbi.nlm.nih.gov/pubmed/36620683 http://dx.doi.org/10.3389/fpsyt.2022.998709 |
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author | Lin, Caigui Hu, Qing Dong, Jiyang Wei, Zhiliang Li, Jie Chen, Zhong |
author_facet | Lin, Caigui Hu, Qing Dong, Jiyang Wei, Zhiliang Li, Jie Chen, Zhong |
author_sort | Lin, Caigui |
collection | PubMed |
description | INTRODUCTION: Schizophrenia (SZ) is a severe chronic mental disorder with increased risk of hepatitis B virus (HBV) infection, which is incurable currently and induces various negative emotions and psychological pressures in patients to exacerbate mental disorders. To facilitate the therapeutic design for SZ patients complicated with HBV infection (SZ + HBV), it is helpful to first elucidate the metabolic perturbations in SZ + HBV patients. METHODS: In this study, metabolic profiles of the serum samples from four groups of participants comprising healthy controls (HC, n = 72), HBV infection (n = 52), SZ patients (n = 37), and SZ + HBV (n = 41) patients were investigated using a high-resolution (1)H NMR-based metabolomics approach. RESULTS AND DISCUSSION: Distinguishable metabolic profiles were found in the four groups. In comparison with HC, HBV infection induced increased levels of citrate and succinate to perturbate the tricarboxylic acid cycle and succinate-related pathways. Similar to SZ cases, SZ + HBV patients exhibited decreased glucose but increased citrate, pyruvate, and lactate, suggesting the occurrence of disturbance in glucose metabolism. Moreover, in comparison with HC, several serum amino acid levels in SZ + HBV patients were significantly altered. Our findings suggest that Warburg effect, energy metabolism disorders, neurotransmitter metabolism abnormalities, mitochondrial dysfunction and several disturbed pathways in relation to tyrosine and choline appear to play specific and central roles in the pathophysiology of SZ + HBV. Apart from replicating metabolic alterations induced by SZ and HBV separately (e.g., in energy metabolism and Warburg effect), the specific metabolic abnormalities in the SZ + HBV group (e.g., several tyrosine- and choline-related pathways) highlighted the existence of a synergistic action between SZ and HBV pathologies. Current study revealed the metabolic alterations specific to the interaction between SZ and HBV pathologies, and may open important perspectives for designing precise therapies for SZ + HBV patients beyond the simple combination of two individual treatments. |
format | Online Article Text |
id | pubmed-9810819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98108192023-01-05 Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study Lin, Caigui Hu, Qing Dong, Jiyang Wei, Zhiliang Li, Jie Chen, Zhong Front Psychiatry Psychiatry INTRODUCTION: Schizophrenia (SZ) is a severe chronic mental disorder with increased risk of hepatitis B virus (HBV) infection, which is incurable currently and induces various negative emotions and psychological pressures in patients to exacerbate mental disorders. To facilitate the therapeutic design for SZ patients complicated with HBV infection (SZ + HBV), it is helpful to first elucidate the metabolic perturbations in SZ + HBV patients. METHODS: In this study, metabolic profiles of the serum samples from four groups of participants comprising healthy controls (HC, n = 72), HBV infection (n = 52), SZ patients (n = 37), and SZ + HBV (n = 41) patients were investigated using a high-resolution (1)H NMR-based metabolomics approach. RESULTS AND DISCUSSION: Distinguishable metabolic profiles were found in the four groups. In comparison with HC, HBV infection induced increased levels of citrate and succinate to perturbate the tricarboxylic acid cycle and succinate-related pathways. Similar to SZ cases, SZ + HBV patients exhibited decreased glucose but increased citrate, pyruvate, and lactate, suggesting the occurrence of disturbance in glucose metabolism. Moreover, in comparison with HC, several serum amino acid levels in SZ + HBV patients were significantly altered. Our findings suggest that Warburg effect, energy metabolism disorders, neurotransmitter metabolism abnormalities, mitochondrial dysfunction and several disturbed pathways in relation to tyrosine and choline appear to play specific and central roles in the pathophysiology of SZ + HBV. Apart from replicating metabolic alterations induced by SZ and HBV separately (e.g., in energy metabolism and Warburg effect), the specific metabolic abnormalities in the SZ + HBV group (e.g., several tyrosine- and choline-related pathways) highlighted the existence of a synergistic action between SZ and HBV pathologies. Current study revealed the metabolic alterations specific to the interaction between SZ and HBV pathologies, and may open important perspectives for designing precise therapies for SZ + HBV patients beyond the simple combination of two individual treatments. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9810819/ /pubmed/36620683 http://dx.doi.org/10.3389/fpsyt.2022.998709 Text en Copyright © 2022 Lin, Hu, Dong, Wei, Li and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Lin, Caigui Hu, Qing Dong, Jiyang Wei, Zhiliang Li, Jie Chen, Zhong Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study |
title | Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study |
title_full | Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study |
title_fullStr | Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study |
title_full_unstemmed | Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study |
title_short | Serum metabolic signatures of schizophrenia patients complicated with hepatitis B virus infection: A (1)H NMR-based metabolomics study |
title_sort | serum metabolic signatures of schizophrenia patients complicated with hepatitis b virus infection: a (1)h nmr-based metabolomics study |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810819/ https://www.ncbi.nlm.nih.gov/pubmed/36620683 http://dx.doi.org/10.3389/fpsyt.2022.998709 |
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