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Role of bioactive compounds in the treatment of hepatitis: A review

Hepatitis causes liver infection leading to inflammation that is swelling of the liver. They are of various types and detrimental to human beings. Natural products have recently been used to develop antiviral drugs against severe viral infections like viral hepatitis. They are usually extracted from...

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Autores principales: Roy, Arpita, Roy, Madhura, Gacem, Amel, Datta, Shreeja, Zeyaullah, Md., Muzammil, Khursheed, Farghaly, Thoraya A., Abdellattif, Magda H., Yadav, Krishna Kumar, Simal-Gandara, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810990/
https://www.ncbi.nlm.nih.gov/pubmed/36618936
http://dx.doi.org/10.3389/fphar.2022.1051751
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author Roy, Arpita
Roy, Madhura
Gacem, Amel
Datta, Shreeja
Zeyaullah, Md.
Muzammil, Khursheed
Farghaly, Thoraya A.
Abdellattif, Magda H.
Yadav, Krishna Kumar
Simal-Gandara, Jesus
author_facet Roy, Arpita
Roy, Madhura
Gacem, Amel
Datta, Shreeja
Zeyaullah, Md.
Muzammil, Khursheed
Farghaly, Thoraya A.
Abdellattif, Magda H.
Yadav, Krishna Kumar
Simal-Gandara, Jesus
author_sort Roy, Arpita
collection PubMed
description Hepatitis causes liver infection leading to inflammation that is swelling of the liver. They are of various types and detrimental to human beings. Natural products have recently been used to develop antiviral drugs against severe viral infections like viral hepatitis. They are usually extracted from herbs or plants and animals. The naturally derived compounds have demonstrated significant antiviral effects against the hepatitis virus and they interfere with different stages of the life cycle of the virus, viral release, replication, and its host-specific interactions. Antiviral activities have been demonstrated by natural products such as phenylpropanoids, flavonoids, xanthones, anthraquinones, terpenoids, alkaloids, aromatics, etc., against hepatitis B and hepatitis C viruses. The recent studies conducted to understand the viral hepatitis life cycle, more effective naturally derived drugs are being produced with a promising future for the treatment of the infection. This review emphasizes the current strategies for treating hepatitis, their shortcomings, the properties of natural products and their numerous types, clinical trials, and future prospects as potential drugs.
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spelling pubmed-98109902023-01-05 Role of bioactive compounds in the treatment of hepatitis: A review Roy, Arpita Roy, Madhura Gacem, Amel Datta, Shreeja Zeyaullah, Md. Muzammil, Khursheed Farghaly, Thoraya A. Abdellattif, Magda H. Yadav, Krishna Kumar Simal-Gandara, Jesus Front Pharmacol Pharmacology Hepatitis causes liver infection leading to inflammation that is swelling of the liver. They are of various types and detrimental to human beings. Natural products have recently been used to develop antiviral drugs against severe viral infections like viral hepatitis. They are usually extracted from herbs or plants and animals. The naturally derived compounds have demonstrated significant antiviral effects against the hepatitis virus and they interfere with different stages of the life cycle of the virus, viral release, replication, and its host-specific interactions. Antiviral activities have been demonstrated by natural products such as phenylpropanoids, flavonoids, xanthones, anthraquinones, terpenoids, alkaloids, aromatics, etc., against hepatitis B and hepatitis C viruses. The recent studies conducted to understand the viral hepatitis life cycle, more effective naturally derived drugs are being produced with a promising future for the treatment of the infection. This review emphasizes the current strategies for treating hepatitis, their shortcomings, the properties of natural products and their numerous types, clinical trials, and future prospects as potential drugs. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9810990/ /pubmed/36618936 http://dx.doi.org/10.3389/fphar.2022.1051751 Text en Copyright © 2022 Roy, Roy, Gacem, Datta, Zeyaullah, Muzammil, Farghaly, Abdellattif, Yadav and Simal-Gandara. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Roy, Arpita
Roy, Madhura
Gacem, Amel
Datta, Shreeja
Zeyaullah, Md.
Muzammil, Khursheed
Farghaly, Thoraya A.
Abdellattif, Magda H.
Yadav, Krishna Kumar
Simal-Gandara, Jesus
Role of bioactive compounds in the treatment of hepatitis: A review
title Role of bioactive compounds in the treatment of hepatitis: A review
title_full Role of bioactive compounds in the treatment of hepatitis: A review
title_fullStr Role of bioactive compounds in the treatment of hepatitis: A review
title_full_unstemmed Role of bioactive compounds in the treatment of hepatitis: A review
title_short Role of bioactive compounds in the treatment of hepatitis: A review
title_sort role of bioactive compounds in the treatment of hepatitis: a review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810990/
https://www.ncbi.nlm.nih.gov/pubmed/36618936
http://dx.doi.org/10.3389/fphar.2022.1051751
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