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Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis
BACKGROUND: To evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS). METHODS: Ancillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and retrospective m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811117/ https://www.ncbi.nlm.nih.gov/pubmed/36619648 http://dx.doi.org/10.3389/fmed.2022.1078325 |
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author | Fernández-Carballido, Cristina Jovaní, Vega Catalán, Emma Beltrán Moreno-Ramos, Manuel José Sanz Sanz, Jesús Gallego, Adela García Vivar, M. Luz Rodríguez-Heredia, José Manuel Sanabra, Cristina Sastré, Carlos |
author_facet | Fernández-Carballido, Cristina Jovaní, Vega Catalán, Emma Beltrán Moreno-Ramos, Manuel José Sanz Sanz, Jesús Gallego, Adela García Vivar, M. Luz Rodríguez-Heredia, José Manuel Sanabra, Cristina Sastré, Carlos |
author_sort | Fernández-Carballido, Cristina |
collection | PubMed |
description | BACKGROUND: To evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS). METHODS: Ancillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and retrospective multicenter nationwide study to assess disease activity and its relationship with HS in clinical practice. Adult patients with AS diagnosis, fulfilling ASAS and modified New York criteria, treated for ≥3 months upon study inclusion according to clinical practice were included. The primary outcome was “disease control” assessed by the percentage of patients in remission and low disease activity (BASDAI and ASDAS-CRP scores). HS was evaluated using the ASAS health index (ASAS-HI). Patients' responses and characteristics were analyzed by gender. RESULTS: We analyzed 313 patients with AS, 237 (75.7%) males and 76 (24.3%) females. A total of 202 (64.5%) patients had adequate disease control (BASDAI < 4); 69.2% of males [mean (SD) BASDAI 2.9 (2.1)] and 50.0% of females [mean (SD) BASDAI 3.8 (2.4); p = 0.01]. According to ASDAS-CRP, 57.5% of patients were adequately controlled (ASDAS-ID +ASDAS-LDA); 138 (58.2%) males and 42 (55.3%) females. The mean (SD) ASDAS-CRP was 1.9 (1.1); being 1.9 (1.0) in males and 2.0 (1.1) in females. Overall, the impact of AS on HS was low to moderate [mean (SD) ASAS-HI 5.8 (4.4)]; being 5.5 (4.4) for males and 6.8 (4.2) for females (p = 0.02). CONCLUSION: This study showed a higher proportion of females with AS and active disease using the BASDAI definition. When using the ASDAS-CRP definition these differences by gender were less pronounced. The impact of disease activity on HS appears to be higher in females than males. |
format | Online Article Text |
id | pubmed-9811117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98111172023-01-05 Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis Fernández-Carballido, Cristina Jovaní, Vega Catalán, Emma Beltrán Moreno-Ramos, Manuel José Sanz Sanz, Jesús Gallego, Adela García Vivar, M. Luz Rodríguez-Heredia, José Manuel Sanabra, Cristina Sastré, Carlos Front Med (Lausanne) Medicine BACKGROUND: To evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS). METHODS: Ancillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and retrospective multicenter nationwide study to assess disease activity and its relationship with HS in clinical practice. Adult patients with AS diagnosis, fulfilling ASAS and modified New York criteria, treated for ≥3 months upon study inclusion according to clinical practice were included. The primary outcome was “disease control” assessed by the percentage of patients in remission and low disease activity (BASDAI and ASDAS-CRP scores). HS was evaluated using the ASAS health index (ASAS-HI). Patients' responses and characteristics were analyzed by gender. RESULTS: We analyzed 313 patients with AS, 237 (75.7%) males and 76 (24.3%) females. A total of 202 (64.5%) patients had adequate disease control (BASDAI < 4); 69.2% of males [mean (SD) BASDAI 2.9 (2.1)] and 50.0% of females [mean (SD) BASDAI 3.8 (2.4); p = 0.01]. According to ASDAS-CRP, 57.5% of patients were adequately controlled (ASDAS-ID +ASDAS-LDA); 138 (58.2%) males and 42 (55.3%) females. The mean (SD) ASDAS-CRP was 1.9 (1.1); being 1.9 (1.0) in males and 2.0 (1.1) in females. Overall, the impact of AS on HS was low to moderate [mean (SD) ASAS-HI 5.8 (4.4)]; being 5.5 (4.4) for males and 6.8 (4.2) for females (p = 0.02). CONCLUSION: This study showed a higher proportion of females with AS and active disease using the BASDAI definition. When using the ASDAS-CRP definition these differences by gender were less pronounced. The impact of disease activity on HS appears to be higher in females than males. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9811117/ /pubmed/36619648 http://dx.doi.org/10.3389/fmed.2022.1078325 Text en Copyright © 2022 Fernández-Carballido, Jovaní, Catalán, Moreno-Ramos, Sanz Sanz, Gallego, García Vivar, Rodríguez-Heredia, Sanabra and Sastré. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Fernández-Carballido, Cristina Jovaní, Vega Catalán, Emma Beltrán Moreno-Ramos, Manuel José Sanz Sanz, Jesús Gallego, Adela García Vivar, M. Luz Rodríguez-Heredia, José Manuel Sanabra, Cristina Sastré, Carlos Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
title | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
title_full | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
title_fullStr | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
title_full_unstemmed | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
title_short | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
title_sort | disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: a real-world nationwide analysis |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811117/ https://www.ncbi.nlm.nih.gov/pubmed/36619648 http://dx.doi.org/10.3389/fmed.2022.1078325 |
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