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Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery

Background: Extended-spectrum β-lactamase (ESBL) producing organisms are resistant to a wide range of broad-spectrum antibiotics, and their emergence is a significant driving force of antibiotic resistance. Most South-Asian countries have become hotspots for antibiotic resistance, so specifics of ES...

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Autores principales: Zahid, Arslan, Aslam, Hina, Zahid, Aayanoor, Ahmed, Iftikhar, Aslam, Saba, Jahanzeb, Zunera, Khalid, Atta-Ul-Aleem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811152/
https://www.ncbi.nlm.nih.gov/pubmed/36620789
http://dx.doi.org/10.7759/cureus.32190
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author Zahid, Arslan
Aslam, Hina
Zahid, Aayanoor
Ahmed, Iftikhar
Aslam, Saba
Jahanzeb, Zunera
Khalid, Atta-Ul-Aleem
author_facet Zahid, Arslan
Aslam, Hina
Zahid, Aayanoor
Ahmed, Iftikhar
Aslam, Saba
Jahanzeb, Zunera
Khalid, Atta-Ul-Aleem
author_sort Zahid, Arslan
collection PubMed
description Background: Extended-spectrum β-lactamase (ESBL) producing organisms are resistant to a wide range of broad-spectrum antibiotics, and their emergence is a significant driving force of antibiotic resistance. Most South-Asian countries have become hotspots for antibiotic resistance, so specifics of ESBL data are critical to tackling antibiotic resistance. We present the temporal changes in ESBL-producing organisms cultured in our tertiary care referral centre. Methods: Over a year, a historical cohort analysis was carried out at our tertiary care referral centre in Southeast Asia. Samples from patients presenting with acute surgical conditions were sent for culture and sensitivity. The phenotype of all specimens was checked using the combination disc method. Antimicrobial susceptibilities to various antibiotics were also checked as per CLSI (Clinical and Laboratory Standard Institute) guidelines. Results: Specimens from 170 patients were analysed. The mean age was 44.73±19.89 years, and there was a female predominance of 62%. The most common organisms were Escherichia coli (70%), Klebsiella pneumoniae (18%), and Pseudomonas aeruginosa (16%). The percentage of ESBL-producing organisms was 54.7%, which is significantly higher than in previous reports. Widespread resistance was found against commonly used antibiotics, including co-amoxiclav (81.9%), ceftriaxone (75%), ciprofloxacin (47%), and levofloxacin (35.7%). Sensitivities to combination antibiotics like piperacillin-tazobactam (79.2% sensitive), cefoperazone-sulbactam (84.3% sensitive), and imipenem-cilastatin (91.1% sensitive) were also noted to be falling. Conclusion: The incidence of ESBL-producing organisms continues to increase at an alarming rate, which mandates strict antibiotic stewardship and amendments to local guidelines.
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spelling pubmed-98111522023-01-05 Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery Zahid, Arslan Aslam, Hina Zahid, Aayanoor Ahmed, Iftikhar Aslam, Saba Jahanzeb, Zunera Khalid, Atta-Ul-Aleem Cureus General Surgery Background: Extended-spectrum β-lactamase (ESBL) producing organisms are resistant to a wide range of broad-spectrum antibiotics, and their emergence is a significant driving force of antibiotic resistance. Most South-Asian countries have become hotspots for antibiotic resistance, so specifics of ESBL data are critical to tackling antibiotic resistance. We present the temporal changes in ESBL-producing organisms cultured in our tertiary care referral centre. Methods: Over a year, a historical cohort analysis was carried out at our tertiary care referral centre in Southeast Asia. Samples from patients presenting with acute surgical conditions were sent for culture and sensitivity. The phenotype of all specimens was checked using the combination disc method. Antimicrobial susceptibilities to various antibiotics were also checked as per CLSI (Clinical and Laboratory Standard Institute) guidelines. Results: Specimens from 170 patients were analysed. The mean age was 44.73±19.89 years, and there was a female predominance of 62%. The most common organisms were Escherichia coli (70%), Klebsiella pneumoniae (18%), and Pseudomonas aeruginosa (16%). The percentage of ESBL-producing organisms was 54.7%, which is significantly higher than in previous reports. Widespread resistance was found against commonly used antibiotics, including co-amoxiclav (81.9%), ceftriaxone (75%), ciprofloxacin (47%), and levofloxacin (35.7%). Sensitivities to combination antibiotics like piperacillin-tazobactam (79.2% sensitive), cefoperazone-sulbactam (84.3% sensitive), and imipenem-cilastatin (91.1% sensitive) were also noted to be falling. Conclusion: The incidence of ESBL-producing organisms continues to increase at an alarming rate, which mandates strict antibiotic stewardship and amendments to local guidelines. Cureus 2022-12-04 /pmc/articles/PMC9811152/ /pubmed/36620789 http://dx.doi.org/10.7759/cureus.32190 Text en Copyright © 2022, Zahid et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle General Surgery
Zahid, Arslan
Aslam, Hina
Zahid, Aayanoor
Ahmed, Iftikhar
Aslam, Saba
Jahanzeb, Zunera
Khalid, Atta-Ul-Aleem
Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery
title Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery
title_full Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery
title_fullStr Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery
title_full_unstemmed Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery
title_short Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery
title_sort temporal changes in extended spectrum β-lactamase producing organisms in acute care surgery
topic General Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811152/
https://www.ncbi.nlm.nih.gov/pubmed/36620789
http://dx.doi.org/10.7759/cureus.32190
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