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Preclinical and Clinical Efficacy of Trastuzumab Deruxtecan in Breast Cancer Brain Metastases

PURPOSE: Brain metastases can occur in up to 50% of patients with metastatic HER2-positive breast cancer. Because patients with active brain metastases were excluded from previous pivotal clinical trials, the central nervous system (CNS) activity of the antibody–drug conjugate trastuzumab deruxtecan...

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Detalles Bibliográficos
Autores principales:	Kabraji, Sheheryar, Ni, Jing, Sammons, Sarah, Li, Tianyu, Van Swearingen, Amanda E.D., Wang, Yanzhi, Pereslete, Alyssa, Hsu, Liangge, DiPiro, Pamela J., Lascola, Chris, Moore, Heather, Hughes, Melissa, Raghavendra, Akshara S., Gule-Monroe, Maria, Murthy, Rashmi K., Winer, Eric P., Anders, Carey K., Zhao, Jean J., Lin, Nancy U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811155/ https://www.ncbi.nlm.nih.gov/pubmed/36074155 http://dx.doi.org/10.1158/1078-0432.CCR-22-1138

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