Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers

Aggregation of genome-wide common risk variants, such as polygenic risk score (PRS), can measure genetic susceptibility to cancer. A better understanding of how common germline variants associate with somatic alterations and clinical features could facilitate personalized cancer prevention and early...

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Detalles Bibliográficos
Autores principales: Namba, Shinichi, Saito, Yuki, Kogure, Yasunori, Masuda, Tatsuo, Bondy, Melissa L., Gharahkhani, Puya, Gockel, Ines, Heider, Dominik, Hillmer, Axel, Jankowski, Janusz, MacGregor, Stuart, Maj, Carlo, Melin, Beatrice, Ostrom, Quinn T., Palles, Claire, Schumacher, Johannes, Tomlinson, Ian, Whiteman, David C., Okada, Yukinori, Kataoka, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Priority Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811159/
https://www.ncbi.nlm.nih.gov/pubmed/36286845
http://dx.doi.org/10.1158/0008-5472.CAN-22-1492

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