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Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA

PURPOSE: Gene fusions are drivers of many pediatric tumors. In fibrolamellar hepatocellular carcinoma (FLC), a fusion of DNAJB1 and PRKACA is the dominant recurrent mutation. Expression of the DNAJB1-PRKACA fusion gene in mice results in a tumor that recapitulates FLC. However, it is not known wheth...

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Detalles Bibliográficos
Autores principales:	Neumayer, Christoph, Ng, Denise, Jiang, Caroline S., Qureshi, Adam, Lalazar, Gadi, Vaughan, Roger, Simon, Sanford M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811160/ https://www.ncbi.nlm.nih.gov/pubmed/36302174 http://dx.doi.org/10.1158/1078-0432.CCR-22-1851

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