Glutamine deamidation does not increase the immunogenicity of C-peptide in people with type 1 diabetes

Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which the insulin-producing beta cells are destroyed. While it is clear that full-length C-peptide, derived from proinsulin, is a major antigen in human T1D it is not clear how and why C-peptide becomes a target of the autoimmune CD4(+...

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Detalles Bibliográficos
Autores principales: Foster, Abby, Bhattacharjee, Pushpak, Tresoldi, Eleonora, Pakusch, Miha, Cameron, Fergus J., Mannering, Stuart I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811213/
https://www.ncbi.nlm.nih.gov/pubmed/36619657
http://dx.doi.org/10.1016/j.jtauto.2022.100180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811213/
https://www.ncbi.nlm.nih.gov/pubmed/36619657
http://dx.doi.org/10.1016/j.jtauto.2022.100180

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