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Glutamine deamidation does not increase the immunogenicity of C-peptide in people with type 1 diabetes
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which the insulin-producing beta cells are destroyed. While it is clear that full-length C-peptide, derived from proinsulin, is a major antigen in human T1D it is not clear how and why C-peptide becomes a target of the autoimmune CD4(+...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811213/ https://www.ncbi.nlm.nih.gov/pubmed/36619657 http://dx.doi.org/10.1016/j.jtauto.2022.100180 |