Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80

Programmed death-ligand 1 (PD-L1) is a key immune regulatory protein that interacts with programmed cell death protein 1 (PD-1), leading to T-cell suppression. Whilst this interaction is key in self-tolerance, cancer cells evade the immune system by overexpressing PD-L1. Inhibition of the PD-1/PD-L1...

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Detalles Bibliográficos
Autores principales: Kang-Pettinger, Tara, Walker, Kayleigh, Brown, Richard, Cowan, Richard, Wright, Helena, Baravalle, Roberta, Waters, Lorna C., Muskett, Frederick W., Bowler, Matthew W., Sawmynaden, Kovilen, Coombs, Peter J., Carr, Mark D., Hall, Gareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811221/
https://www.ncbi.nlm.nih.gov/pubmed/36470427
http://dx.doi.org/10.1016/j.jbc.2022.102769

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