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Design and synthesis of a clickable, photoreactive amino acid p-(4-(but-3-yn-1-yl)benzoyl)-l-phenylalanine for peptide photoaffinity labeling

Photoaffinity labeling is a powerful technique to investigate the interactions between bioactive peptides and their targets. To construct a peptide-derived photoaffinity probe, at least two amino acids need to be modified or replaced, increasing experimental difficulties and negatively affecting act...

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Detalles Bibliográficos
Autores principales: Han, Penggang, Wang, Fuli, Bao, Shaoheng, Yao, Ge, Wan, Xiukun, Liu, JiaJia, Jiang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811243/
https://www.ncbi.nlm.nih.gov/pubmed/36686919
http://dx.doi.org/10.1039/d2ra07248c