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Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases

We aimed to evaluate the association between leisure-time physical activity (PA) and mortality risk in adults with major chronic diseases. A total of 170,579 adults with major chronic diseases aged 30–84 years from the U.S. National Health Interview Surveys (1997–2014) with linkage to the National D...

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Autores principales: Sun, Jiahong, Wu, Han, Zhao, Min, Magnussen, Costan G., Xi, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811256/
https://www.ncbi.nlm.nih.gov/pubmed/36618699
http://dx.doi.org/10.3389/fnut.2022.1048238
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author Sun, Jiahong
Wu, Han
Zhao, Min
Magnussen, Costan G.
Xi, Bo
author_facet Sun, Jiahong
Wu, Han
Zhao, Min
Magnussen, Costan G.
Xi, Bo
author_sort Sun, Jiahong
collection PubMed
description We aimed to evaluate the association between leisure-time physical activity (PA) and mortality risk in adults with major chronic diseases. A total of 170,579 adults with major chronic diseases aged 30–84 years from the U.S. National Health Interview Surveys (1997–2014) with linkage to the National Death Index (NDI) through December 31, 2015 were included in this study. During a median follow-up of 7.25 years, 36,914 adults with chronic diseases died from all causes, 8,767 died from cardiovascular disease (CVD), and 9,090 died from cancer. Compared with participants with no leisure-time PA, those with a low level (10–59 min/week) of total leisure-time PA had a 23% [hazard ratio (HR) 0.77, 95% confidence interval (CI) 0.73–0.82] reduced risk of all-cause mortality. Adults with higher levels of leisure time had more reduced risk of all-cause mortality, as well as CVD-specific and cancer-specific mortality. Adults with leisure-time PA ≥ 1,500 min/week had more reduced risk of CVD-specific mortality (61%) but less reduced risk of cancer-specific mortality (29%) compared with the reduced risk of all-cause mortality (43%). There was an inversely non-linear dose-response relationship between leisure-time PA and all-cause and cause-specific mortality. Reduced risk of all-cause and cancer-specific mortality between leisure-time light-to-moderate PA and vigorous-intensity PA time were largely comparable. Low and high levels of leisure-time PA showed substantial survival benefits compared with no leisure-time PA in adults with major chronic diseases. The light-to-moderate-intensity leisure-time PA is largely comparable with vigorous PA to provide survival benefits for all-cause and cancer-specific mortality.
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spelling pubmed-98112562023-01-05 Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases Sun, Jiahong Wu, Han Zhao, Min Magnussen, Costan G. Xi, Bo Front Nutr Nutrition We aimed to evaluate the association between leisure-time physical activity (PA) and mortality risk in adults with major chronic diseases. A total of 170,579 adults with major chronic diseases aged 30–84 years from the U.S. National Health Interview Surveys (1997–2014) with linkage to the National Death Index (NDI) through December 31, 2015 were included in this study. During a median follow-up of 7.25 years, 36,914 adults with chronic diseases died from all causes, 8,767 died from cardiovascular disease (CVD), and 9,090 died from cancer. Compared with participants with no leisure-time PA, those with a low level (10–59 min/week) of total leisure-time PA had a 23% [hazard ratio (HR) 0.77, 95% confidence interval (CI) 0.73–0.82] reduced risk of all-cause mortality. Adults with higher levels of leisure time had more reduced risk of all-cause mortality, as well as CVD-specific and cancer-specific mortality. Adults with leisure-time PA ≥ 1,500 min/week had more reduced risk of CVD-specific mortality (61%) but less reduced risk of cancer-specific mortality (29%) compared with the reduced risk of all-cause mortality (43%). There was an inversely non-linear dose-response relationship between leisure-time PA and all-cause and cause-specific mortality. Reduced risk of all-cause and cancer-specific mortality between leisure-time light-to-moderate PA and vigorous-intensity PA time were largely comparable. Low and high levels of leisure-time PA showed substantial survival benefits compared with no leisure-time PA in adults with major chronic diseases. The light-to-moderate-intensity leisure-time PA is largely comparable with vigorous PA to provide survival benefits for all-cause and cancer-specific mortality. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9811256/ /pubmed/36618699 http://dx.doi.org/10.3389/fnut.2022.1048238 Text en Copyright © 2022 Sun, Wu, Zhao, Magnussen and Xi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Sun, Jiahong
Wu, Han
Zhao, Min
Magnussen, Costan G.
Xi, Bo
Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases
title Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases
title_full Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases
title_fullStr Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases
title_full_unstemmed Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases
title_short Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases
title_sort dose-response association of leisure time physical activity with mortality in adults with major chronic diseases
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811256/
https://www.ncbi.nlm.nih.gov/pubmed/36618699
http://dx.doi.org/10.3389/fnut.2022.1048238
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