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The circadian clock component BMAL1 regulates osteogenesis in osseointegration

Congenital and developmental craniofacial deformities often cause bone defects, misalignment, and soft tissue asymmetry, which can lead to facial function and morphologic abnormalities, especially among children born with cleft lip and palate. Joint efforts from oral maxillofacial surgery, oral impl...

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Autores principales: Deng, Shiyong, Qi, Meiyao, Gong, Ping, Tan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811265/
https://www.ncbi.nlm.nih.gov/pubmed/36619505
http://dx.doi.org/10.3389/fped.2022.1091296
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author Deng, Shiyong
Qi, Meiyao
Gong, Ping
Tan, Zhen
author_facet Deng, Shiyong
Qi, Meiyao
Gong, Ping
Tan, Zhen
author_sort Deng, Shiyong
collection PubMed
description Congenital and developmental craniofacial deformities often cause bone defects, misalignment, and soft tissue asymmetry, which can lead to facial function and morphologic abnormalities, especially among children born with cleft lip and palate. Joint efforts from oral maxillofacial surgery, oral implantology, and cosmetic surgery are often required for diagnosis and treatment. As one of the most widely performed treatment methods, implant-supported cranio-maxillofacial prostheses have been widely applied in the course of treatment. Therefore, stability of peri-implant bone tissue is crucial for the long-term success of treatment and patients’ quality of life. The circadian clock component brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) was found to be involved in the cell fate of bone marrow mesenchymal stem cells, which were essential in the fixation of titanium implants. This study aimed to investigate the effect of BMAL1 on osteogenesis in osseointegration, providing a brand new solution to increase bone implant conjunction efficiency and implant stability, paving the way for a long-term satisfactory therapy outcome.
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spelling pubmed-98112652023-01-05 The circadian clock component BMAL1 regulates osteogenesis in osseointegration Deng, Shiyong Qi, Meiyao Gong, Ping Tan, Zhen Front Pediatr Pediatrics Congenital and developmental craniofacial deformities often cause bone defects, misalignment, and soft tissue asymmetry, which can lead to facial function and morphologic abnormalities, especially among children born with cleft lip and palate. Joint efforts from oral maxillofacial surgery, oral implantology, and cosmetic surgery are often required for diagnosis and treatment. As one of the most widely performed treatment methods, implant-supported cranio-maxillofacial prostheses have been widely applied in the course of treatment. Therefore, stability of peri-implant bone tissue is crucial for the long-term success of treatment and patients’ quality of life. The circadian clock component brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) was found to be involved in the cell fate of bone marrow mesenchymal stem cells, which were essential in the fixation of titanium implants. This study aimed to investigate the effect of BMAL1 on osteogenesis in osseointegration, providing a brand new solution to increase bone implant conjunction efficiency and implant stability, paving the way for a long-term satisfactory therapy outcome. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9811265/ /pubmed/36619505 http://dx.doi.org/10.3389/fped.2022.1091296 Text en © 2022 Deng, Qi, Gong and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Deng, Shiyong
Qi, Meiyao
Gong, Ping
Tan, Zhen
The circadian clock component BMAL1 regulates osteogenesis in osseointegration
title The circadian clock component BMAL1 regulates osteogenesis in osseointegration
title_full The circadian clock component BMAL1 regulates osteogenesis in osseointegration
title_fullStr The circadian clock component BMAL1 regulates osteogenesis in osseointegration
title_full_unstemmed The circadian clock component BMAL1 regulates osteogenesis in osseointegration
title_short The circadian clock component BMAL1 regulates osteogenesis in osseointegration
title_sort circadian clock component bmal1 regulates osteogenesis in osseointegration
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811265/
https://www.ncbi.nlm.nih.gov/pubmed/36619505
http://dx.doi.org/10.3389/fped.2022.1091296
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