Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)

Mechanism of Superenhancer‐Driven LncRNA Accelerating Lipid Metabolism In article number 2204711, Li Peng and co‐workers reveal the mechanism of superenhancer‐related lncRNA functioning in lipid metabolism. It can be simulated by the accelerating vehicle. LncRNA FASRL is transcriptionally driven by...

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Autores principales: Peng, Jiang‐Yun, Cai, Dian‐Kui, Zeng, Ren‐Li, Zhang, Chao‐Yang, Li, Guan‐Cheng, Chen, Si‐Fan, Yuan, Xiao‐Qing, Peng, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Inside Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811430/
http://dx.doi.org/10.1002/advs.202370004
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author Peng, Jiang‐Yun
Cai, Dian‐Kui
Zeng, Ren‐Li
Zhang, Chao‐Yang
Li, Guan‐Cheng
Chen, Si‐Fan
Yuan, Xiao‐Qing
Peng, Li
author_facet Peng, Jiang‐Yun
Cai, Dian‐Kui
Zeng, Ren‐Li
Zhang, Chao‐Yang
Li, Guan‐Cheng
Chen, Si‐Fan
Yuan, Xiao‐Qing
Peng, Li
author_sort Peng, Jiang‐Yun
collection PubMed
description Mechanism of Superenhancer‐Driven LncRNA Accelerating Lipid Metabolism In article number 2204711, Li Peng and co‐workers reveal the mechanism of superenhancer‐related lncRNA functioning in lipid metabolism. It can be simulated by the accelerating vehicle. LncRNA FASRL is transcriptionally driven by USF1 via its superenhancer. FASRL binding to ACACA, a fatty acid synthesis rate‐limiting enzyme, increases lipid accumulation to exacerbate HCC. [Image: see text]
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spelling pubmed-98114302023-01-05 Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023) Peng, Jiang‐Yun Cai, Dian‐Kui Zeng, Ren‐Li Zhang, Chao‐Yang Li, Guan‐Cheng Chen, Si‐Fan Yuan, Xiao‐Qing Peng, Li Adv Sci (Weinh) Inside Back Cover Mechanism of Superenhancer‐Driven LncRNA Accelerating Lipid Metabolism In article number 2204711, Li Peng and co‐workers reveal the mechanism of superenhancer‐related lncRNA functioning in lipid metabolism. It can be simulated by the accelerating vehicle. LncRNA FASRL is transcriptionally driven by USF1 via its superenhancer. FASRL binding to ACACA, a fatty acid synthesis rate‐limiting enzyme, increases lipid accumulation to exacerbate HCC. [Image: see text] John Wiley and Sons Inc. 2023-01-04 /pmc/articles/PMC9811430/ http://dx.doi.org/10.1002/advs.202370004 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Inside Back Cover
Peng, Jiang‐Yun
Cai, Dian‐Kui
Zeng, Ren‐Li
Zhang, Chao‐Yang
Li, Guan‐Cheng
Chen, Si‐Fan
Yuan, Xiao‐Qing
Peng, Li
Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)
title Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)
title_full Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)
title_fullStr Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)
title_full_unstemmed Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)
title_short Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)
title_sort upregulation of superenhancer‐driven lncrna fasrl by usf1 promotes de novo fatty acid biosynthesis to exacerbate hepatocellular carcinoma (adv. sci. 1/2023)
topic Inside Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811430/
http://dx.doi.org/10.1002/advs.202370004
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