Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates

[Image: see text] L-type amino acid transporter 1 (LAT1) transfers essential amino acids across cell membranes. Owing to its predominant expression in the blood–brain barrier and tumor cells, LAT1 has been exploited for drug delivery and targeting to the central nervous system (CNS) and various canc...

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Detalles Bibliográficos
Autores principales: Bahrami, Katayun, Järvinen, Juulia, Laitinen, Tuomo, Reinisalo, Mika, Honkakoski, Paavo, Poso, Antti, Huttunen, Kristiina M., Rautio, Jarkko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811466/
https://www.ncbi.nlm.nih.gov/pubmed/36394563
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811466/
https://www.ncbi.nlm.nih.gov/pubmed/36394563
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00594

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