Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: penetration speed of cyclosporin A across lipid bilayers

Cyclic peptides that passively penetrate cell membranes are under active investigation in drug discovery research. PAMPA (Parallel Artificial Membrane Permeability Assay) and Caco-2 assay are mainly used for permeability measurements in these studies. However, permeability rates across the artificia...

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Detalles Bibliográficos
Autores principales: Ono, Takahiro, Tabata, Kazuhito V., Goto, Yuki, Saito, Yutaro, Suga, Hiroaki, Noji, Hiroyuki, Morimoto, Jumpei, Sando, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811578/
https://www.ncbi.nlm.nih.gov/pubmed/36687349
http://dx.doi.org/10.1039/d2sc05785a

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