Cargando…

High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons

Cortical neuronal networks control cognitive output, but their composition and modulation remain elusive. Here, we studied the morphological and transcriptional diversity of cortical cholinergic VIP/ChAT interneurons (VChIs), a sparse population with a largely unknown function. We focused on VChIs f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yayon, Nadav, Amsalem, Oren, Zorbaz, Tamara, Yakov, Or, Dubnov, Serafima, Winek, Katarzyna, Dudai, Amir, Adam, Gil, Schmidtner, Anna K, Tessier‐Lavigne, Marc, Renier, Nicolas, Habib, Naomi, Segev, Idan, London, Michael, Soreq, Hermona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811618/ https://www.ncbi.nlm.nih.gov/pubmed/36377476 http://dx.doi.org/10.15252/embj.2021110565

Ejemplares similares

Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo
por: Dudai, Amir, et al.
Publicado: (2020)

Intensify3D: Normalizing signal intensity in large heterogenic image stacks
por: Yayon, Nadav, et al.
Publicado: (2018)

Sex-specific declines in cholinergic-targeting tRNA fragments in the nucleus accumbens in Alzheimer’s disease
por: Shulman, Dana, et al.
Publicado: (2023)

Cholinergic blockade of neuroinflammation: from tissue to RNA regulators
por: Zorbaz, Tamara, et al.
Publicado: (2022)

Regulators of cholinergic signaling in disorders of the central nervous system
por: Winek, Katarzyna, et al.
Publicado: (2021)

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade
por: Winek, Katarzyna, et al.
Publicado: (2020)

Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease
por: Gok, Muslum, et al.
Publicado: (2022)

Personalized genetics of the cholinergic blockade of neuroinflammation
por: Simchovitz, Alon, et al.
Publicado: (2017)

Gut feeling: MicroRNA discriminators of the intestinal TLR9–cholinergic links
por: Nadorp, Bettina, et al.
Publicado: (2015)

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
por: Obermayer, Joshua, et al.
Publicado: (2019)

Author Correction: Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
por: Obermayer, Joshua, et al.
Publicado: (2020)

The Neat Dance of COVID-19: NEAT1, DANCR, and Co-Modulated Cholinergic RNAs Link to Inflammation
por: Meydan, Chanan, et al.
Publicado: (2020)

A lncRNA survey finds increases in neuroprotective LINC‐PINT in Parkinson’s disease substantia nigra
por: Simchovitz, Alon, et al.
Publicado: (2020)

Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder
por: Lobentanzer, Sebastian, et al.
Publicado: (2019)

Establishing Human Male and Female Models of Cholinergic Neurons via Neurokine-Mediated Differentiation of LA-N-2 and LA-N-5 Neuroblastoma Cells
por: Lobentanzer, Sebastian, et al.
Publicado: (2020)

Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis
por: Gnatek, Yehudit, et al.
Publicado: (2012)

NEAT1 is overexpressed in Parkinson’s disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress
por: Simchovitz, Alon, et al.
Publicado: (2019)

Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions
por: Meerson, Ari, et al.
Publicado: (2009)

The Role of Hub Neurons in Modulating Cortical Dynamics
por: Gal, Eyal, et al.
Publicado: (2021)

Cholinergic Stress Signals Accompany MicroRNA-Associated Stereotypic Behavior and Glutamatergic Neuromodulation in the Prefrontal Cortex
por: Moshitzky, Gilli, et al.
Publicado: (2020)

Cholinergic regulation of vascular endothelial function by human ChAT(+) T cells
por: Tarnawski, Laura, et al.
Publicado: (2023)

Distinct CholinomiR Blood Cell Signature as a Potential Modulator of the Cholinergic System in Women with Fibromyalgia Syndrome
por: Erbacher, Christoph, et al.
Publicado: (2022)

Novel roles of non-coding brain RNAs in health and disease
por: Soreq, Hermona
Publicado: (2014)

MicroRNA-target interactions in neurodegenerative diseases
por: Soreq, Hermona
Publicado: (2015)

Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice
por: Berson, Amit, et al.
Publicado: (2012)

Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network
por: Lefler, Yaara, et al.
Publicado: (2020)

From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells
por: Amsalem, Oren, et al.
Publicado: (2016)

Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes
por: Hanin, Geula, et al.
Publicado: (2011)

Acetylcholinesterase: old questions and new developments
por: Tsim, Karl, et al.
Publicado: (2013)

Statistically invalid classification of high throughput gene expression data
por: Barbash, Shahar, et al.
Publicado: (2013)

Predicted overlapping microRNA regulators of acetylcholine packaging and degradation in neuroinflammation-related disorders
por: Nadorp, Bettina, et al.
Publicado: (2014)

It All Starts at the Ends: Multifaceted Involvement of C- and N-Terminally Modified Cholinesterases in Alzheimer’s Disease
por: Berson, Amit, et al.
Publicado: (2010)

Cholino‐ncRNAs modulate sex‐specific‐ and age‐related acetylcholine signals
por: Madrer, Nimrod, et al.
Publicado: (2020)

Competing targets of microRNA-608 affect anxiety and hypertension
por: Hanin, Geula, et al.
Publicado: (2014)

Competing targets of microRNA-608 affect anxiety and hypertension
por: Hanin, Geula, et al.
Publicado: (2014)

Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes
por: Soreq, Lilach, et al.
Publicado: (2013)

A Parkinson's disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress
por: Hanan, Mor, et al.
Publicado: (2020)

An efficient analytical reduction of detailed nonlinear neuron models
por: Amsalem, Oren, et al.
Publicado: (2020)

Realistic retinal modeling unravels the differential role of excitation and inhibition to starburst amacrine cells in direction selectivity
por: Ezra-Tsur, Elishai, et al.
Publicado: (2021)

Analyzing alternative splicing data of splice junction arrays from Parkinson patients' leukocytes before and after deep brain stimulation as compared with control donors
por: Soreq, Lilach, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_nisa5ntrb11rig92kbbg4kas8m