Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model

BACKGROUND: Drug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of the right therapeutic targets and the right drugs for combating the disease. METHODS: Here, we present a system...

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Detalles Bibliográficos
Autores principales: Chen, Yun-Ti, Chang, Yu-Hsiu, Pathak, Nikhil, Tzou, Shey-Cherng, Luo, Yong-Chun, Hsu, Yen-Chao, Li, Tian-Neng, Lee, Jung-Yu, Chen, Yi-Cyun, Huang, Yu-Wei, Yang, Hsin-Ju, Hsu, Nung-Yu, Tsai, Hui-Ping, Chang, Tein-Yao, Hsu, Shu-Chen, Liu, Ping-Cheng, Chin, Yuan-Fan, Lin, Wen-Chin, Yang, Chuen-Mi, Wu, Hsueh-Ling, Lee, Chia-Ying, Hsu, Hui-Ling, Liu, Yi-Chun, Chu, Jhih-Wei, Wang, Lily Hui-Ching, Wang, Jann-Yuan, Huang, Chih-Heng, Lin, Chi-Hung, Hsieh, Po-Shiuan, Wu Lee, Yan-Hwa, Hung, Yi-Jen, Yang, Jinn-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811668/
https://www.ncbi.nlm.nih.gov/pubmed/36618412
http://dx.doi.org/10.3389/fimmu.2022.1080897

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