Improved predictions of antigen presentation and TCR recognition with MixMHCpred2.2 and PRIME2.0 reveal potent SARS-CoV-2 CD8(+) T-cell epitopes

The recognition of pathogen or cancer-specific epitopes by CD8(+) T cells is crucial for the clearance of infections and the response to cancer immunotherapy. This process requires epitopes to be presented on class I human leukocyte antigen (HLA-I) molecules and recognized by the T-cell receptor (TC...

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Autores principales: Gfeller, David, Schmidt, Julien, Croce, Giancarlo, Guillaume, Philippe, Bobisse, Sara, Genolet, Raphael, Queiroz, Lise, Cesbron, Julien, Racle, Julien, Harari, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811684/
https://www.ncbi.nlm.nih.gov/pubmed/36603583
http://dx.doi.org/10.1016/j.cels.2022.12.002

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