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Subunit microparticulate vaccine delivery using microneedles trigger significant SARS-spike-specific humoral and cellular responses in a preclinical murine model

The objective of this “proof-of-concept” study was to evaluate the synergistic effect of a subunit microparticulate vaccine and microneedles (MN) assisted vaccine delivery system against a human coronavirus. Here, we formulated PLGA polymeric microparticles (MPs) encapsulating spike glycoprotein (GP...

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Detalles Bibliográficos
Autores principales:	Patil, Smital, Vijayanand, Sharon, Joshi, Devyani, Menon, Ipshita, Braz Gomes, Keegan, Kale, Akanksha, Bagwe, Priyal, Yacoub, Shadi, Uddin, Mohammad N., D'Souza, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811858/ https://www.ncbi.nlm.nih.gov/pubmed/36610521 http://dx.doi.org/10.1016/j.ijpharm.2023.122583

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