2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations

Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, meth...

Descripción completa

Detalles Bibliográficos
Autores principales: Riesco-Llach, Gerard, Planas, Marta, Feliu, Lidia, Joule, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811941/
https://www.ncbi.nlm.nih.gov/pubmed/36686909
http://dx.doi.org/10.1039/d2ra07227k
_version_ 1784863629925941248
author Riesco-Llach, Gerard
Planas, Marta
Feliu, Lidia
Joule, John A.
author_facet Riesco-Llach, Gerard
Planas, Marta
Feliu, Lidia
Joule, John A.
author_sort Riesco-Llach, Gerard
collection PubMed
description Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021.
format Online
Article
Text
id pubmed-9811941
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-98119412023-01-20 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations Riesco-Llach, Gerard Planas, Marta Feliu, Lidia Joule, John A. RSC Adv Chemistry Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021. The Royal Society of Chemistry 2023-01-04 /pmc/articles/PMC9811941/ /pubmed/36686909 http://dx.doi.org/10.1039/d2ra07227k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Riesco-Llach, Gerard
Planas, Marta
Feliu, Lidia
Joule, John A.
2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
title 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
title_full 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
title_fullStr 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
title_full_unstemmed 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
title_short 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
title_sort 2(1h)-pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811941/
https://www.ncbi.nlm.nih.gov/pubmed/36686909
http://dx.doi.org/10.1039/d2ra07227k
work_keys_str_mv AT riescollachgerard 21hpyrazinonesfromacyclicbuildingblocksmethodsofsynthesisandfurtherderivatizations
AT planasmarta 21hpyrazinonesfromacyclicbuildingblocksmethodsofsynthesisandfurtherderivatizations
AT feliulidia 21hpyrazinonesfromacyclicbuildingblocksmethodsofsynthesisandfurtherderivatizations
AT joulejohna 21hpyrazinonesfromacyclicbuildingblocksmethodsofsynthesisandfurtherderivatizations

Ejemplares similares