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The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics

The adolescent brain undergoes tremendous structural and functional changes throughout puberty. Previous research has demonstrated that pubertal hormones can modulate sexually dimorphic changes in cortical development, as well as age‐related maturation of the neural activity underlying cognitive pro...

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Autores principales: Fung, Madison H., Rahman, Raeef L., Taylor, Brittany K., Frenzel, Michaela R., Eastman, Jacob A., Wang, Yu‐Ping, Calhoun, Vince D., Stephen, Julia M., Wilson, Tony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812248/
https://www.ncbi.nlm.nih.gov/pubmed/35778797
http://dx.doi.org/10.1002/hbm.25991
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author Fung, Madison H.
Rahman, Raeef L.
Taylor, Brittany K.
Frenzel, Michaela R.
Eastman, Jacob A.
Wang, Yu‐Ping
Calhoun, Vince D.
Stephen, Julia M.
Wilson, Tony W.
author_facet Fung, Madison H.
Rahman, Raeef L.
Taylor, Brittany K.
Frenzel, Michaela R.
Eastman, Jacob A.
Wang, Yu‐Ping
Calhoun, Vince D.
Stephen, Julia M.
Wilson, Tony W.
author_sort Fung, Madison H.
collection PubMed
description The adolescent brain undergoes tremendous structural and functional changes throughout puberty. Previous research has demonstrated that pubertal hormones can modulate sexually dimorphic changes in cortical development, as well as age‐related maturation of the neural activity underlying cognitive processes. However, the precise impact of pubertal hormones on these functional changes in the developing human brain remains poorly understood. In the current study, we quantified the neural oscillatory activity serving visuospatial processing using magnetoencephalography, and utilized measures of dehydroepiandrosterone (DHEA) as an index of development during the transition from childhood to adolescence (i.e., puberty). Within a sample of typically developing youth (ages 9–15), a novel association between pubertal DHEA and theta oscillatory activity indicated that less mature children exhibited stronger neural responses in higher‐order prefrontal cortices during the visuospatial task. Theta coherence between bilateral prefrontal regions also increased with increasing DHEA, such that network‐level theta activity became more distributed with more maturity. Additionally, significant DHEA‐by‐sex interactions in the gamma range were centered on cortical regions relevant for attention processing. These findings suggest that pubertal DHEA may modulate the development of neural oscillatory activity serving visuospatial processing and attention functions during the pubertal period.
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spelling pubmed-98122482023-01-05 The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics Fung, Madison H. Rahman, Raeef L. Taylor, Brittany K. Frenzel, Michaela R. Eastman, Jacob A. Wang, Yu‐Ping Calhoun, Vince D. Stephen, Julia M. Wilson, Tony W. Hum Brain Mapp Research Articles The adolescent brain undergoes tremendous structural and functional changes throughout puberty. Previous research has demonstrated that pubertal hormones can modulate sexually dimorphic changes in cortical development, as well as age‐related maturation of the neural activity underlying cognitive processes. However, the precise impact of pubertal hormones on these functional changes in the developing human brain remains poorly understood. In the current study, we quantified the neural oscillatory activity serving visuospatial processing using magnetoencephalography, and utilized measures of dehydroepiandrosterone (DHEA) as an index of development during the transition from childhood to adolescence (i.e., puberty). Within a sample of typically developing youth (ages 9–15), a novel association between pubertal DHEA and theta oscillatory activity indicated that less mature children exhibited stronger neural responses in higher‐order prefrontal cortices during the visuospatial task. Theta coherence between bilateral prefrontal regions also increased with increasing DHEA, such that network‐level theta activity became more distributed with more maturity. Additionally, significant DHEA‐by‐sex interactions in the gamma range were centered on cortical regions relevant for attention processing. These findings suggest that pubertal DHEA may modulate the development of neural oscillatory activity serving visuospatial processing and attention functions during the pubertal period. John Wiley & Sons, Inc. 2022-07-01 /pmc/articles/PMC9812248/ /pubmed/35778797 http://dx.doi.org/10.1002/hbm.25991 Text en © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Fung, Madison H.
Rahman, Raeef L.
Taylor, Brittany K.
Frenzel, Michaela R.
Eastman, Jacob A.
Wang, Yu‐Ping
Calhoun, Vince D.
Stephen, Julia M.
Wilson, Tony W.
The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
title The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
title_full The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
title_fullStr The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
title_full_unstemmed The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
title_short The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
title_sort impact of pubertal dhea on the development of visuospatial oscillatory dynamics
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812248/
https://www.ncbi.nlm.nih.gov/pubmed/35778797
http://dx.doi.org/10.1002/hbm.25991
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