Cargando…
Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein
The BA.2 sub-lineage of the Omicron (B.1.1.529) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant rapidly supplanted the original BA.1 sub-lineage in early 2022. Both lineages threatened the efficacy of vaccine-elicited antibodies and acquired increased binding to several mammalia...
Autores principales: | Saville, James W., Mannar, Dhiraj, Zhu, Xing, Berezuk, Alison M., Cholak, Spencer, Tuttle, Katharine S., Vahdatihassani, Faezeh, Subramaniam, Sriram |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812370/ https://www.ncbi.nlm.nih.gov/pubmed/36640338 http://dx.doi.org/10.1016/j.celrep.2022.111964 |
Ejemplares similares
-
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
por: Mannar, Dhiraj, et al.
Publicado: (2022) -
Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
por: Saville, James W., et al.
Publicado: (2022) -
Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
por: Zhu, Xing, et al.
Publicado: (2021) -
Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding
por: Mannar, Dhiraj, et al.
Publicado: (2021) -
Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry
por: Mannar, Dhiraj, et al.
Publicado: (2021)