Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19

Spleen tyrosine kinase (SYK) is a previously unidentified therapeutic target that inhibits neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19). Fostamatinib, a SYK inhibitor, was studied in a phase 2 placebo-controlled randomized clinical trial and was associated with improve...

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Detalles Bibliográficos
Autores principales: Wigerblad, Gustaf, Warner, Seth A., Ramos-Benitez, Marcos J., Kardava, Lela, Tian, Xin, Miao, Rui, Reger, Robert, Chakraborty, Mala, Wong, Susan, Kanthi, Yogendra, Suffredini, Anthony F., Dell’Orso, Stefania, Brooks, Stephen, King, Christopher, Shlobin, Oksana, Nathan, Steven D., Cohen, Jonathan, Moir, Susan, Childs, Richard W., Kaplan, Mariana J., Chertow, Daniel S., Strich, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812373/
https://www.ncbi.nlm.nih.gov/pubmed/36598976
http://dx.doi.org/10.1126/sciadv.ade8272

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