Cargando…

Dynamic metabolome profiling uncovers potential TOR signaling genes

Although the genetic code of the yeast Saccharomyces cerevisiae was sequenced 25 years ago, the characterization of the roles of genes within it is far from complete. The lack of a complete mapping of functions to genes hampers systematic understanding of the biology of the cell. The advent of high-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reichling, Stella, Doubleday, Peter F, Germade, Tomas, Bergmann, Ariane, Loewith, Robbie, Sauer, Uwe, Holbrook-Smith, Duncan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812406/ https://www.ncbi.nlm.nih.gov/pubmed/36598488 http://dx.doi.org/10.7554/eLife.84295

Ejemplares similares

Uncovering the secret life of Rho GTPases
por: Perry, Jenna A, et al.
Publicado: (2019)

Z-REX uncovers a bifurcation in function of Keap1 paralogs
por: Van Hall-Beauvais, Alexandra, et al.
Publicado: (2022)

Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library
por: Lite, Thuy-Lan V, et al.
Publicado: (2020)

Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery
por: Ngan, Kevin Chun-Ho, et al.
Publicado: (2023)

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
por: Chen, Xiangrong, et al.
Publicado: (2021)

Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation
por: Iosub, Ira Alexandra, et al.
Publicado: (2020)

Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate
por: Li, Wan Hua, et al.
Publicado: (2021)

Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES
por: Pisareva, Vera P, et al.
Publicado: (2018)

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
por: Heimhalt, Maren, et al.
Publicado: (2021)

The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and Ageing-Related metabolites
por: Medley, J Kyle, et al.
Publicado: (2022)

The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics
por: Bonicelli, Andrea, et al.
Publicado: (2022)

Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding
por: Bell, Tristan A, et al.
Publicado: (2019)

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
por: Kim, Sora, et al.
Publicado: (2020)

Temporal profiling of redox-dependent heterogeneity in single cells
por: Radzinski, Meytal, et al.
Publicado: (2018)

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
por: Amberg-Johnson, Katherine, et al.
Publicado: (2017)

Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries
por: Carlson, Michael Luke, et al.
Publicado: (2019)

Listeria monocytogenes requires cellular respiration for NAD(+) regeneration and pathogenesis
por: Rivera-Lugo, Rafael, et al.
Publicado: (2022)

Cryo-EM reveals distinct conformations of E. coli ATP synthase on exposure to ATP
por: Sobti, Meghna, et al.
Publicado: (2019)

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs
por: van de Kooij, Bert, et al.
Publicado: (2019)

A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution
por: Mohammad, Fuad, et al.
Publicado: (2019)

Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation
por: Miyazaki, Ryoji, et al.
Publicado: (2020)

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells
por: Kulthawatsiri, Thanaporn, et al.
Publicado: (2023)

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display
por: Li, Allyson, et al.
Publicado: (2023)

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions
por: Rademacher, Nils, et al.
Publicado: (2019)

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
por: Avet, Charlotte, et al.
Publicado: (2022)

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
por: Kollewe, Astrid, et al.
Publicado: (2021)

Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3
por: Becker, Florian, et al.
Publicado: (2023)

ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery
por: Corey, Robin A, et al.
Publicado: (2019)

Group II intron inhibits conjugative relaxase expression in bacteria by mRNA targeting
por: Qu, Guosheng, et al.
Publicado: (2018)

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules
por: Hagenbuchner, Judith, et al.
Publicado: (2019)

Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments
por: Smith, Quentin M, et al.
Publicado: (2021)

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor
por: Ahorukomeye, Peter, et al.
Publicado: (2019)

Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
por: Stratiievska, Anastasiia, et al.
Publicado: (2018)

Identification of host proteins differentially associated with HIV-1 RNA splice variants
por: Knoener, Rachel, et al.
Publicado: (2021)

Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNP
por: Hansen, Sarah R, et al.
Publicado: (2022)

Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing
por: Thapa, Dibesh, et al.
Publicado: (2021)

Molecular basis for multimerization in the activation of the epidermal growth factor receptor
por: Huang, Yongjian, et al.
Publicado: (2016)

Subcellular drug targeting illuminates local kinase action
por: Bucko, Paula J, et al.
Publicado: (2019)

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice
por: Jo, Youngah, et al.
Publicado: (2019)

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma
por: Turnham, Rigney E, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_95dlpkha55qtf6mfo22du7nu01