Cargando…

A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma

A 59-year-old man was admitted to our hospital in August 2020 because of fever with night sweats and weight loss. The patient was eventually diagnosed with synchronous triple primary malignancies: diffuse large B-cell lymphoma (DLBCL), rectal adenocarcinoma and hepatocellular carcinoma (HCC), which...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Beixuan, Lin, Cheng, Wu, Lupeng, Li, Yifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812437/
https://www.ncbi.nlm.nih.gov/pubmed/36620610
http://dx.doi.org/10.3389/fonc.2022.1046878
_version_ 1784863726109720576
author Qiu, Beixuan
Lin, Cheng
Wu, Lupeng
Li, Yifei
author_facet Qiu, Beixuan
Lin, Cheng
Wu, Lupeng
Li, Yifei
author_sort Qiu, Beixuan
collection PubMed
description A 59-year-old man was admitted to our hospital in August 2020 because of fever with night sweats and weight loss. The patient was eventually diagnosed with synchronous triple primary malignancies: diffuse large B-cell lymphoma (DLBCL), rectal adenocarcinoma and hepatocellular carcinoma (HCC), which has not been reported previously. The patient initially received six cycles of R-Gemox chemotherapy targeting DLBCL, the response to the treatment was partial remission. We continued six cycles of R-CHOP therapy, and DLBCL achieved a complete remission to treatment. During R-CHOP chemotherapy, PD-1 inhibitor (Sintilimab) was used to control the disease progression of HCC, which was effective and tolerable. Subsequently, he successfully completed curative intent Dixon operation and right hemihepatectomy. The diagnosis and treatment for like these synchronous triple primary malignancies are a huge challenge, herein we provide our experience in this regard.
format Online
Article
Text
id pubmed-9812437
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98124372023-01-05 A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma Qiu, Beixuan Lin, Cheng Wu, Lupeng Li, Yifei Front Oncol Oncology A 59-year-old man was admitted to our hospital in August 2020 because of fever with night sweats and weight loss. The patient was eventually diagnosed with synchronous triple primary malignancies: diffuse large B-cell lymphoma (DLBCL), rectal adenocarcinoma and hepatocellular carcinoma (HCC), which has not been reported previously. The patient initially received six cycles of R-Gemox chemotherapy targeting DLBCL, the response to the treatment was partial remission. We continued six cycles of R-CHOP therapy, and DLBCL achieved a complete remission to treatment. During R-CHOP chemotherapy, PD-1 inhibitor (Sintilimab) was used to control the disease progression of HCC, which was effective and tolerable. Subsequently, he successfully completed curative intent Dixon operation and right hemihepatectomy. The diagnosis and treatment for like these synchronous triple primary malignancies are a huge challenge, herein we provide our experience in this regard. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9812437/ /pubmed/36620610 http://dx.doi.org/10.3389/fonc.2022.1046878 Text en Copyright © 2022 Qiu, Lin, Wu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Qiu, Beixuan
Lin, Cheng
Wu, Lupeng
Li, Yifei
A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
title A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
title_full A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
title_fullStr A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
title_full_unstemmed A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
title_short A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
title_sort case report of synchronous triple primary malignancies: diffuse large b-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812437/
https://www.ncbi.nlm.nih.gov/pubmed/36620610
http://dx.doi.org/10.3389/fonc.2022.1046878
work_keys_str_mv AT qiubeixuan acasereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma
AT lincheng acasereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma
AT wulupeng acasereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma
AT liyifei acasereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma
AT qiubeixuan casereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma
AT lincheng casereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma
AT wulupeng casereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma
AT liyifei casereportofsynchronoustripleprimarymalignanciesdiffuselargebcelllymphomarectaladenocarcinomaandhepatocellularcarcinoma