Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity

The medicinal plants were wildly library of natural products in drug discovery. The most active molecules with seven-membered rings skeleton represent a challenge for construction. A stereoselectivity (4 + 3) cycloadditions between allenyl ethers and substituted furans induced by chiral auxiliaries...

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Autores principales: Lei, Wenli, Song, Yuyang, Long, Ai, Que, Yanyan, He, Shuzhong, Zhong, Hang, Chen, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Plant Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812524/
https://www.ncbi.nlm.nih.gov/pubmed/36618658
http://dx.doi.org/10.3389/fpls.2022.1087899
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author Lei, Wenli
Song, Yuyang
Long, Ai
Que, Yanyan
He, Shuzhong
Zhong, Hang
Chen, Yang
author_facet Lei, Wenli
Song, Yuyang
Long, Ai
Que, Yanyan
He, Shuzhong
Zhong, Hang
Chen, Yang
author_sort Lei, Wenli
collection PubMed
description The medicinal plants were wildly library of natural products in drug discovery. The most active molecules with seven-membered rings skeleton represent a challenge for construction. A stereoselectivity (4 + 3) cycloadditions between allenyl ethers and substituted furans induced by chiral auxiliaries has been investigated. And the results showed significant stereoselectivities and regioselectivities. The optical cycloadducts with an oxygen-substituted seven-membered ring framework were generated by removing chiral auxiliaries under acidic conditions. The antiproliferative activity of the novel compounds displayed moderate antiproliferative effects toward T47D cells.
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spelling pubmed-98125242023-01-05 Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity Lei, Wenli Song, Yuyang Long, Ai Que, Yanyan He, Shuzhong Zhong, Hang Chen, Yang Front Plant Sci Plant Science The medicinal plants were wildly library of natural products in drug discovery. The most active molecules with seven-membered rings skeleton represent a challenge for construction. A stereoselectivity (4 + 3) cycloadditions between allenyl ethers and substituted furans induced by chiral auxiliaries has been investigated. And the results showed significant stereoselectivities and regioselectivities. The optical cycloadducts with an oxygen-substituted seven-membered ring framework were generated by removing chiral auxiliaries under acidic conditions. The antiproliferative activity of the novel compounds displayed moderate antiproliferative effects toward T47D cells. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9812524/ /pubmed/36618658 http://dx.doi.org/10.3389/fpls.2022.1087899 Text en Copyright © 2022 Lei, Song, Long, Que, He, Zhong and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Lei, Wenli
Song, Yuyang
Long, Ai
Que, Yanyan
He, Shuzhong
Zhong, Hang
Chen, Yang
Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity
title Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity
title_full Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity
title_fullStr Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity
title_full_unstemmed Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity
title_short Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity
title_sort stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812524/
https://www.ncbi.nlm.nih.gov/pubmed/36618658
http://dx.doi.org/10.3389/fpls.2022.1087899
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