Takotsubo Cardiomyopathy in the Setting of Myxedema Coma

Myxedema coma and its treatment are potent physical stressors that likely predispose patients to develop Takotsubo cardiomyopathy (TCM). We postulate a multifactorial pathophysiology for TCM that includes a mechanism involving catecholamine-induced potentiation of cardiac adrenoreceptors during thyr...

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Autores principales: Chan, Eric K, Brown, Cameron, Bachar, Roudi, Smith, Antonio, Srivangipuram, Sudarsana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812530/
https://www.ncbi.nlm.nih.gov/pubmed/36620783
http://dx.doi.org/10.7759/cureus.32229
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author Chan, Eric K
Brown, Cameron
Bachar, Roudi
Smith, Antonio
Srivangipuram, Sudarsana
author_facet Chan, Eric K
Brown, Cameron
Bachar, Roudi
Smith, Antonio
Srivangipuram, Sudarsana
author_sort Chan, Eric K
collection PubMed
description Myxedema coma and its treatment are potent physical stressors that likely predispose patients to develop Takotsubo cardiomyopathy (TCM). We postulate a multifactorial pathophysiology for TCM that includes a mechanism involving catecholamine-induced potentiation of cardiac adrenoreceptors during thyroid hormone replacement in the setting of severe hypothyroidism. Furthermore, TCM can be difficult to anticipate when presenting as a complication of another diagnosis. In this case report, we aim to improve awareness of TCM as a consequence of extreme hypothyroid states. 
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spelling pubmed-98125302023-01-05 Takotsubo Cardiomyopathy in the Setting of Myxedema Coma Chan, Eric K Brown, Cameron Bachar, Roudi Smith, Antonio Srivangipuram, Sudarsana Cureus Cardiology Myxedema coma and its treatment are potent physical stressors that likely predispose patients to develop Takotsubo cardiomyopathy (TCM). We postulate a multifactorial pathophysiology for TCM that includes a mechanism involving catecholamine-induced potentiation of cardiac adrenoreceptors during thyroid hormone replacement in the setting of severe hypothyroidism. Furthermore, TCM can be difficult to anticipate when presenting as a complication of another diagnosis. In this case report, we aim to improve awareness of TCM as a consequence of extreme hypothyroid states.  Cureus 2022-12-05 /pmc/articles/PMC9812530/ /pubmed/36620783 http://dx.doi.org/10.7759/cureus.32229 Text en Copyright © 2022, Chan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Chan, Eric K
Brown, Cameron
Bachar, Roudi
Smith, Antonio
Srivangipuram, Sudarsana
Takotsubo Cardiomyopathy in the Setting of Myxedema Coma
title Takotsubo Cardiomyopathy in the Setting of Myxedema Coma
title_full Takotsubo Cardiomyopathy in the Setting of Myxedema Coma
title_fullStr Takotsubo Cardiomyopathy in the Setting of Myxedema Coma
title_full_unstemmed Takotsubo Cardiomyopathy in the Setting of Myxedema Coma
title_short Takotsubo Cardiomyopathy in the Setting of Myxedema Coma
title_sort takotsubo cardiomyopathy in the setting of myxedema coma
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812530/
https://www.ncbi.nlm.nih.gov/pubmed/36620783
http://dx.doi.org/10.7759/cureus.32229
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