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Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice

The causal mechanisms and manifestations of psychiatric illness cannot be neatly narrowed down or quantified for diagnosis and treatment. Large-scale genome-wide association studies (GWAS) might renew hope for locating genetic predictors and producing precision medicines, however such hopes can also...

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Autores principales: Brown, Julia E. H., Young, Jennifer L., Martinez-Martin, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812559/
https://www.ncbi.nlm.nih.gov/pubmed/36620660
http://dx.doi.org/10.3389/fpsyt.2022.1061705
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author Brown, Julia E. H.
Young, Jennifer L.
Martinez-Martin, Nicole
author_facet Brown, Julia E. H.
Young, Jennifer L.
Martinez-Martin, Nicole
author_sort Brown, Julia E. H.
collection PubMed
description The causal mechanisms and manifestations of psychiatric illness cannot be neatly narrowed down or quantified for diagnosis and treatment. Large-scale genome-wide association studies (GWAS) might renew hope for locating genetic predictors and producing precision medicines, however such hopes can also distract from appreciating social factors and structural injustices that demand more socially inclusive and equitable approaches to mental healthcare. A more comprehensive approach begins with recognizing that there is no one type of contributor to mental illness and its duration that should be prioritized over another. We argue that, if the search for biological specificity is to complement the need to alleviate the social distress that produces mental health inequities, psychiatric genomics must incorporate an intersectional dimension to models of mental illness across research priorities, scientific frameworks, and clinical applications. We outline an intersectional framework that will guide all professionals working in the expanding field of psychiatric genomics to better incorporate issues of social context, racial and cultural diversity, and downstream ethical considerations into their work.
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spelling pubmed-98125592023-01-05 Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice Brown, Julia E. H. Young, Jennifer L. Martinez-Martin, Nicole Front Psychiatry Psychiatry The causal mechanisms and manifestations of psychiatric illness cannot be neatly narrowed down or quantified for diagnosis and treatment. Large-scale genome-wide association studies (GWAS) might renew hope for locating genetic predictors and producing precision medicines, however such hopes can also distract from appreciating social factors and structural injustices that demand more socially inclusive and equitable approaches to mental healthcare. A more comprehensive approach begins with recognizing that there is no one type of contributor to mental illness and its duration that should be prioritized over another. We argue that, if the search for biological specificity is to complement the need to alleviate the social distress that produces mental health inequities, psychiatric genomics must incorporate an intersectional dimension to models of mental illness across research priorities, scientific frameworks, and clinical applications. We outline an intersectional framework that will guide all professionals working in the expanding field of psychiatric genomics to better incorporate issues of social context, racial and cultural diversity, and downstream ethical considerations into their work. Frontiers Media S.A. 2022-12-21 /pmc/articles/PMC9812559/ /pubmed/36620660 http://dx.doi.org/10.3389/fpsyt.2022.1061705 Text en Copyright © 2022 Brown, Young and Martinez-Martin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Brown, Julia E. H.
Young, Jennifer L.
Martinez-Martin, Nicole
Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice
title Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice
title_full Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice
title_fullStr Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice
title_full_unstemmed Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice
title_short Psychiatric genomics, mental health equity, and intersectionality: A framework for research and practice
title_sort psychiatric genomics, mental health equity, and intersectionality: a framework for research and practice
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812559/
https://www.ncbi.nlm.nih.gov/pubmed/36620660
http://dx.doi.org/10.3389/fpsyt.2022.1061705
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