Rare FGFR Oncogenic Alterations in Sequenced Pediatric Solid and Brain Tumors Suggest FGFR Is a Relevant Molecular Target in Childhood Cancer

Multiple FGFR inhibitors are currently in clinical trials enrolling adults with different solid tumors, while very few enroll pediatric patients. We determined the types and frequency of FGFR alterations (FGFR1-4) in pediatric cancers to inform future clinical trial design. METHODS: Tumors with FGFR...

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Detalles Bibliográficos
Autores principales: Lazo De La Vega, Lorena, Comeau, Hannah, Sallan, Sarah, Al-Ibraheemi, Alyaa, Gupta, Hersh, Li, Yvonne Y., Tsai, Harrison K., Kang, Wenjun, Ward, Abigail, Church, Alanna J., Kim, AeRang, Pinto, Navin R., Macy, Margaret E., Maese, Luke D., Sabnis, Amit J., Cherniack, Andrew D., Lindeman, Neal I., Anderson, Megan E., Cooney, Tabitha M., Yeo, Kee Kiat, Reaman, Gregory H., DuBois, Steven G., Collins, Natalie B., Johnson, Bruce E., Janeway, Katherine A., Forrest, Suzanne J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2022
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812632/
https://www.ncbi.nlm.nih.gov/pubmed/36446043
http://dx.doi.org/10.1200/PO.22.00390

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