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Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia

BACKGROUND: Resting-state functional connectivity (rs-FC) may aid in understanding the link between pain-modulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in res...

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Autores principales: Soldatelli, Matheus, Franco, Álvaro de Oliveira, Picon, Felipe, Duarte, Juliana Ávila, Scherer, Ricardo, Bandeira, Janete, Zortea, Maxciel, Torres, Iraci Lucena da Silva, Fregni, Felipe, Caumo, Wolnei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Pain Society 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812696/
https://www.ncbi.nlm.nih.gov/pubmed/36581601
http://dx.doi.org/10.3344/kjp.22225
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author Soldatelli, Matheus
Franco, Álvaro de Oliveira
Picon, Felipe
Duarte, Juliana Ávila
Scherer, Ricardo
Bandeira, Janete
Zortea, Maxciel
Torres, Iraci Lucena da Silva
Fregni, Felipe
Caumo, Wolnei
author_facet Soldatelli, Matheus
Franco, Álvaro de Oliveira
Picon, Felipe
Duarte, Juliana Ávila
Scherer, Ricardo
Bandeira, Janete
Zortea, Maxciel
Torres, Iraci Lucena da Silva
Fregni, Felipe
Caumo, Wolnei
author_sort Soldatelli, Matheus
collection PubMed
description BACKGROUND: Resting-state functional connectivity (rs-FC) may aid in understanding the link between pain-modulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. METHODS: This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. RESULTS: Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63–0.94) to discriminate who does/does not respond to the CPM-test. CONCLUSIONS: These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.
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spelling pubmed-98126962023-01-11 Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia Soldatelli, Matheus Franco, Álvaro de Oliveira Picon, Felipe Duarte, Juliana Ávila Scherer, Ricardo Bandeira, Janete Zortea, Maxciel Torres, Iraci Lucena da Silva Fregni, Felipe Caumo, Wolnei Korean J Pain Clinical Research Articles BACKGROUND: Resting-state functional connectivity (rs-FC) may aid in understanding the link between pain-modulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. METHODS: This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. RESULTS: Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63–0.94) to discriminate who does/does not respond to the CPM-test. CONCLUSIONS: These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients. The Korean Pain Society 2023-01-01 2023-01-01 /pmc/articles/PMC9812696/ /pubmed/36581601 http://dx.doi.org/10.3344/kjp.22225 Text en © The Korean Pain Society, 2023 https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Articles
Soldatelli, Matheus
Franco, Álvaro de Oliveira
Picon, Felipe
Duarte, Juliana Ávila
Scherer, Ricardo
Bandeira, Janete
Zortea, Maxciel
Torres, Iraci Lucena da Silva
Fregni, Felipe
Caumo, Wolnei
Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
title Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
title_full Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
title_fullStr Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
title_full_unstemmed Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
title_short Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
title_sort primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
topic Clinical Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812696/
https://www.ncbi.nlm.nih.gov/pubmed/36581601
http://dx.doi.org/10.3344/kjp.22225
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