A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential

We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5‐fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET pred...

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Detalles Bibliográficos
Autores principales: Pandey, Prem, Chaturvedi, Supriya, Gumathannavar, Rutuja, Shirolkar, Mandar M., Kanuru, Vijay, Kulkarni, Atul, Moh, Sang Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812755/
https://www.ncbi.nlm.nih.gov/pubmed/36599688
http://dx.doi.org/10.1002/open.202200200
Descripción
Sumario:We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5‐fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET predictors.

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