A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential

We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5‐fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET pred...

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Autores principales: Pandey, Prem, Chaturvedi, Supriya, Gumathannavar, Rutuja, Shirolkar, Mandar M., Kanuru, Vijay, Kulkarni, Atul, Moh, Sang Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812755/
https://www.ncbi.nlm.nih.gov/pubmed/36599688
http://dx.doi.org/10.1002/open.202200200
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author Pandey, Prem
Chaturvedi, Supriya
Gumathannavar, Rutuja
Shirolkar, Mandar M.
Kanuru, Vijay
Kulkarni, Atul
Moh, Sang Hyun
author_facet Pandey, Prem
Chaturvedi, Supriya
Gumathannavar, Rutuja
Shirolkar, Mandar M.
Kanuru, Vijay
Kulkarni, Atul
Moh, Sang Hyun
author_sort Pandey, Prem
collection PubMed
description We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5‐fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET predictors.
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spelling pubmed-98127552023-01-05 A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential Pandey, Prem Chaturvedi, Supriya Gumathannavar, Rutuja Shirolkar, Mandar M. Kanuru, Vijay Kulkarni, Atul Moh, Sang Hyun ChemistryOpen Research Articles We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5‐fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET predictors. John Wiley and Sons Inc. 2023-01-04 /pmc/articles/PMC9812755/ /pubmed/36599688 http://dx.doi.org/10.1002/open.202200200 Text en © 2023 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Pandey, Prem
Chaturvedi, Supriya
Gumathannavar, Rutuja
Shirolkar, Mandar M.
Kanuru, Vijay
Kulkarni, Atul
Moh, Sang Hyun
A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential
title A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential
title_full A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential
title_fullStr A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential
title_full_unstemmed A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential
title_short A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential
title_sort xanthan‐gum‐stabilized peg‐conjugated nanocurcumin complex: telescoping synthesis for enhanced permeation potential
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812755/
https://www.ncbi.nlm.nih.gov/pubmed/36599688
http://dx.doi.org/10.1002/open.202200200
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