Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

Immune checkpoint blockade (ICB) has substantially improved the prognosis of patients with cancer, but the majority experiences limited benefit, supporting the need for new therapeutic approaches. Up-regulation of sialic acid–containing glycans, termed hypersialylation, is a common feature of cancer...

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Detalles Bibliográficos
Autores principales: Stanczak, Michal A., Mantuano, Natalia Rodrigues, Kirchhammer, Nicole, Sanin, David E., Jacob, Francis, Coelho, Ricardo, Everest-Dass, Arun V., Wang, Jinyu, Trefny, Marcel P., Monaco, Gianni, Bärenwaldt, Anne, Gray, Melissa A., Petrone, Adam, Kashyap, Abhishek S., Glatz, Katharina, Kasenda, Benjamin, Normington, Karl, Broderick, James, Peng, Li, Pearce, Oliver M.T., Pearce, Erika L., Bertozzi, Carolyn R., Zippelius, Alfred, Läubli, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812757/
https://www.ncbi.nlm.nih.gov/pubmed/36322632
http://dx.doi.org/10.1126/scitranslmed.abj1270

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