Recurrent repeat expansions in human cancer genomes

Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to cause more than 50 diseases(1,2). However, repeat expansions are often not explored beyond neurological and neurodegenerative disorders. In some cancers, mutations accumulate in short tracts of TRs, a phenomenon...

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Autores principales: Erwin, Graham S., Gürsoy, Gamze, Al-Abri, Rashid, Suriyaprakash, Ashwini, Dolzhenko, Egor, Zhu, Kevin, Hoerner, Christian R., White, Shannon M., Ramirez, Lucia, Vadlakonda, Ananya, Vadlakonda, Alekhya, von Kraut, Konor, Park, Julia, Brannon, Charlotte M., Sumano, Daniel A., Kirtikar, Raushun A., Erwin, Alicia A., Metzner, Thomas J., Yuen, Ryan K. C., Fan, Alice C., Leppert, John T., Eberle, Michael A., Gerstein, Mark, Snyder, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812771/
https://www.ncbi.nlm.nih.gov/pubmed/36517591
http://dx.doi.org/10.1038/s41586-022-05515-1

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