Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis

Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated huma...

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Detalles Bibliográficos
Autores principales: Rabino, Martina, Rurali, Erica, Zamboni, Chiara, Rovina, Davide, Mallia, Sara, Cauteruccio, Matteo, Baggiano, Andrea, Giacari, Carlo Maria, Bellin, Milena, Pompilio, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2023
Materias:
Lab Resource: Multiple Cell Lines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812822/
https://www.ncbi.nlm.nih.gov/pubmed/36630840
http://dx.doi.org/10.1016/j.scr.2023.103018
Descripción
Sumario:Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations.

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