Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis

Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated huma...

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Autores principales: Rabino, Martina, Rurali, Erica, Zamboni, Chiara, Rovina, Davide, Mallia, Sara, Cauteruccio, Matteo, Baggiano, Andrea, Giacari, Carlo Maria, Bellin, Milena, Pompilio, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2023
Materias:
Lab Resource: Multiple Cell Lines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812822/
https://www.ncbi.nlm.nih.gov/pubmed/36630840
http://dx.doi.org/10.1016/j.scr.2023.103018
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author Rabino, Martina
Rurali, Erica
Zamboni, Chiara
Rovina, Davide
Mallia, Sara
Cauteruccio, Matteo
Baggiano, Andrea
Giacari, Carlo Maria
Bellin, Milena
Pompilio, Giulio
author_facet Rabino, Martina
Rurali, Erica
Zamboni, Chiara
Rovina, Davide
Mallia, Sara
Cauteruccio, Matteo
Baggiano, Andrea
Giacari, Carlo Maria
Bellin, Milena
Pompilio, Giulio
author_sort Rabino, Martina
collection PubMed
description Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations.
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spelling pubmed-98128222023-01-05 Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis Rabino, Martina Rurali, Erica Zamboni, Chiara Rovina, Davide Mallia, Sara Cauteruccio, Matteo Baggiano, Andrea Giacari, Carlo Maria Bellin, Milena Pompilio, Giulio Stem Cell Res Lab Resource: Multiple Cell Lines Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations. The Author(s). Published by Elsevier B.V. 2023-03 2023-01-05 /pmc/articles/PMC9812822/ /pubmed/36630840 http://dx.doi.org/10.1016/j.scr.2023.103018 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Lab Resource: Multiple Cell Lines
Rabino, Martina
Rurali, Erica
Zamboni, Chiara
Rovina, Davide
Mallia, Sara
Cauteruccio, Matteo
Baggiano, Andrea
Giacari, Carlo Maria
Bellin, Milena
Pompilio, Giulio
Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
title Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
title_full Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
title_fullStr Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
title_full_unstemmed Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
title_short Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
title_sort generation of four human induced pluripotent stem cell lines from covid-19 hospitalized patients with increased levels of cardiac troponin in the acute infection phase developing or not myocarditis
topic Lab Resource: Multiple Cell Lines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812822/
https://www.ncbi.nlm.nih.gov/pubmed/36630840
http://dx.doi.org/10.1016/j.scr.2023.103018
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