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The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice
In male mice, the transcription factors STRA8 and MEISON initiate meiosis I. We report that STRA8/MEISON activates the transcription factors A-MYB and TCFL5, which together reprogram gene expression after spermatogonia enter into meiosis. TCFL5 promotes transcription of genes required for meiosis, m...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812935/ https://www.ncbi.nlm.nih.gov/pubmed/36395073 http://dx.doi.org/10.1530/REP-22-0355 |
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author | Cecchini, Katharine Biasini, Adriano Yu, Tianxiong Säflund, Martin Mou, Haiwei Arif, Amena Eghbali, Atiyeh Colpan, Cansu Gainetdinov, Ildar de Rooij, Dirk G. Weng, Zhiping Zamore, Phillip D. Özata, Deniz M. |
author_facet | Cecchini, Katharine Biasini, Adriano Yu, Tianxiong Säflund, Martin Mou, Haiwei Arif, Amena Eghbali, Atiyeh Colpan, Cansu Gainetdinov, Ildar de Rooij, Dirk G. Weng, Zhiping Zamore, Phillip D. Özata, Deniz M. |
author_sort | Cecchini, Katharine |
collection | PubMed |
description | In male mice, the transcription factors STRA8 and MEISON initiate meiosis I. We report that STRA8/MEISON activates the transcription factors A-MYB and TCFL5, which together reprogram gene expression after spermatogonia enter into meiosis. TCFL5 promotes transcription of genes required for meiosis, mRNA turnover, miR-34/449 production, meiotic exit, and spermiogenesis. This transcriptional architecture is conserved in rhesus macaque, suggesting TCFL5 plays a central role in meiosis and spermiogenesis in placental mammals. Tcfl5(em1/em1) mutants are sterile, and spermatogenesis arrests at the mid- or late-pachytene stage of meiosis. Moreover, Tcfl5(+/em1) mutants produce fewer motile sperm. |
format | Online Article Text |
id | pubmed-9812935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-98129352023-02-01 The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice Cecchini, Katharine Biasini, Adriano Yu, Tianxiong Säflund, Martin Mou, Haiwei Arif, Amena Eghbali, Atiyeh Colpan, Cansu Gainetdinov, Ildar de Rooij, Dirk G. Weng, Zhiping Zamore, Phillip D. Özata, Deniz M. Reproduction Article In male mice, the transcription factors STRA8 and MEISON initiate meiosis I. We report that STRA8/MEISON activates the transcription factors A-MYB and TCFL5, which together reprogram gene expression after spermatogonia enter into meiosis. TCFL5 promotes transcription of genes required for meiosis, mRNA turnover, miR-34/449 production, meiotic exit, and spermiogenesis. This transcriptional architecture is conserved in rhesus macaque, suggesting TCFL5 plays a central role in meiosis and spermiogenesis in placental mammals. Tcfl5(em1/em1) mutants are sterile, and spermatogenesis arrests at the mid- or late-pachytene stage of meiosis. Moreover, Tcfl5(+/em1) mutants produce fewer motile sperm. 2023-02-01 2023-01-04 /pmc/articles/PMC9812935/ /pubmed/36395073 http://dx.doi.org/10.1530/REP-22-0355 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Cecchini, Katharine Biasini, Adriano Yu, Tianxiong Säflund, Martin Mou, Haiwei Arif, Amena Eghbali, Atiyeh Colpan, Cansu Gainetdinov, Ildar de Rooij, Dirk G. Weng, Zhiping Zamore, Phillip D. Özata, Deniz M. The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice |
title | The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice |
title_full | The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice |
title_fullStr | The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice |
title_full_unstemmed | The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice |
title_short | The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice |
title_sort | transcription factor tcfl5 responds to a-myb to elaborate the male meiotic program in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812935/ https://www.ncbi.nlm.nih.gov/pubmed/36395073 http://dx.doi.org/10.1530/REP-22-0355 |
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