Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis

Insulin acts through the insulin receptor (IR) tyrosine kinase to exert its classical metabolic and mitogenic actions. Here, using receptors with either short or long deletion of the β-subunit or mutation of the kinase active site (K1030R), we have uncovered a second, previously unrecognized IR sign...

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Detalles Bibliográficos
Autores principales: Nagao, Hirofumi, Jayavelu, Ashok Kumar, Cai, Weikang, Pan, Hui, Dreyfuss, Jonathan M., Batista, Thiago M., Brandão, Bruna B., Mann, Matthias, Kahn, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812992/
https://www.ncbi.nlm.nih.gov/pubmed/36599833
http://dx.doi.org/10.1038/s41467-022-35693-5

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