Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma

Lactic acidosis has been reported in solid tumor microenvironment (TME) including glioblastoma (GBM). In TME, several signaling molecules, growth factors and metabolites have been identified to induce resistance to chemotherapy and to sustain immune escape. In the early phases of the disease, microg...

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Detalles Bibliográficos
Autores principales: Longhitano, Lucia, Vicario, Nunzio, Forte, Stefano, Giallongo, Cesarina, Broggi, Giuseppe, Caltabiano, Rosario, Barbagallo, Giuseppe Maria Vincenzo, Altieri, Roberto, Raciti, Giuseppina, Di Rosa, Michelino, Caruso, Massimo, Parenti, Rosalba, Liso, Arcangelo, Busi, Federica, Lolicato, Marco, Mione, Maria Caterina, Li Volti, Giovanni, Tibullo, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813126/
https://www.ncbi.nlm.nih.gov/pubmed/35654889
http://dx.doi.org/10.1007/s00262-022-03215-3

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