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The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools

INTRODUCTION: In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems. METHODS: This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, an...

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Autores principales: Filser, Melanie, Buchner, Axel, Fink, Gereon Rudolf, Gold, Stefan M., Penner, Iris-Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813146/
https://www.ncbi.nlm.nih.gov/pubmed/36129540
http://dx.doi.org/10.1007/s00415-022-11359-6
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author Filser, Melanie
Buchner, Axel
Fink, Gereon Rudolf
Gold, Stefan M.
Penner, Iris-Katharina
author_facet Filser, Melanie
Buchner, Axel
Fink, Gereon Rudolf
Gold, Stefan M.
Penner, Iris-Katharina
author_sort Filser, Melanie
collection PubMed
description INTRODUCTION: In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems. METHODS: This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, anxiety, bipolar disorder, euphoria, and pseudobulbar affect. Furthermore, the association between affective symptoms and quality of life and the currently used diagnostic instruments for assessing these symptoms are considered whereby relevant studies published between 2009 and 2021 were included in the review. RESULTS: Patients with mild and moderate disability more frequently reported severe problems with depression and anxiety than severe mobility problems. Apart from the occurrence of depression, little is known about the association of other affective symptoms such as anxiety, bipolar disorder, euphoria, and pseudobulbar affect and subsyndromal symptoms, which fail to meet the diagnostic criteria but are nevertheless a significant source of distress. Although there are a few recommendations in the research to perform routine screenings for diagnosable affective disorders, a standardized diagnostic procedure to assess subsyndromal symptoms is still lacking. As the applied measurements are diverse and show low accuracy to detect these symptoms, patients who experience affective symptoms are less likely to be identified. DISCUSSION: In addition to the consideration of definite psychiatric diagnoses, there is an unmet need for a common definition and assessment of disease-related affective symptoms in MS. Future studies should focus on the improvement and standardization of a common diagnostic procedure for subsyndromal affective symptoms in MS to enable integrated and optimal care for patients.
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spelling pubmed-98131462023-01-06 The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools Filser, Melanie Buchner, Axel Fink, Gereon Rudolf Gold, Stefan M. Penner, Iris-Katharina J Neurol Review INTRODUCTION: In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems. METHODS: This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, anxiety, bipolar disorder, euphoria, and pseudobulbar affect. Furthermore, the association between affective symptoms and quality of life and the currently used diagnostic instruments for assessing these symptoms are considered whereby relevant studies published between 2009 and 2021 were included in the review. RESULTS: Patients with mild and moderate disability more frequently reported severe problems with depression and anxiety than severe mobility problems. Apart from the occurrence of depression, little is known about the association of other affective symptoms such as anxiety, bipolar disorder, euphoria, and pseudobulbar affect and subsyndromal symptoms, which fail to meet the diagnostic criteria but are nevertheless a significant source of distress. Although there are a few recommendations in the research to perform routine screenings for diagnosable affective disorders, a standardized diagnostic procedure to assess subsyndromal symptoms is still lacking. As the applied measurements are diverse and show low accuracy to detect these symptoms, patients who experience affective symptoms are less likely to be identified. DISCUSSION: In addition to the consideration of definite psychiatric diagnoses, there is an unmet need for a common definition and assessment of disease-related affective symptoms in MS. Future studies should focus on the improvement and standardization of a common diagnostic procedure for subsyndromal affective symptoms in MS to enable integrated and optimal care for patients. Springer Berlin Heidelberg 2022-09-21 2023 /pmc/articles/PMC9813146/ /pubmed/36129540 http://dx.doi.org/10.1007/s00415-022-11359-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Filser, Melanie
Buchner, Axel
Fink, Gereon Rudolf
Gold, Stefan M.
Penner, Iris-Katharina
The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
title The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
title_full The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
title_fullStr The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
title_full_unstemmed The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
title_short The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
title_sort manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813146/
https://www.ncbi.nlm.nih.gov/pubmed/36129540
http://dx.doi.org/10.1007/s00415-022-11359-6
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