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The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools
INTRODUCTION: In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems. METHODS: This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813146/ https://www.ncbi.nlm.nih.gov/pubmed/36129540 http://dx.doi.org/10.1007/s00415-022-11359-6 |
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author | Filser, Melanie Buchner, Axel Fink, Gereon Rudolf Gold, Stefan M. Penner, Iris-Katharina |
author_facet | Filser, Melanie Buchner, Axel Fink, Gereon Rudolf Gold, Stefan M. Penner, Iris-Katharina |
author_sort | Filser, Melanie |
collection | PubMed |
description | INTRODUCTION: In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems. METHODS: This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, anxiety, bipolar disorder, euphoria, and pseudobulbar affect. Furthermore, the association between affective symptoms and quality of life and the currently used diagnostic instruments for assessing these symptoms are considered whereby relevant studies published between 2009 and 2021 were included in the review. RESULTS: Patients with mild and moderate disability more frequently reported severe problems with depression and anxiety than severe mobility problems. Apart from the occurrence of depression, little is known about the association of other affective symptoms such as anxiety, bipolar disorder, euphoria, and pseudobulbar affect and subsyndromal symptoms, which fail to meet the diagnostic criteria but are nevertheless a significant source of distress. Although there are a few recommendations in the research to perform routine screenings for diagnosable affective disorders, a standardized diagnostic procedure to assess subsyndromal symptoms is still lacking. As the applied measurements are diverse and show low accuracy to detect these symptoms, patients who experience affective symptoms are less likely to be identified. DISCUSSION: In addition to the consideration of definite psychiatric diagnoses, there is an unmet need for a common definition and assessment of disease-related affective symptoms in MS. Future studies should focus on the improvement and standardization of a common diagnostic procedure for subsyndromal affective symptoms in MS to enable integrated and optimal care for patients. |
format | Online Article Text |
id | pubmed-9813146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-98131462023-01-06 The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools Filser, Melanie Buchner, Axel Fink, Gereon Rudolf Gold, Stefan M. Penner, Iris-Katharina J Neurol Review INTRODUCTION: In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems. METHODS: This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, anxiety, bipolar disorder, euphoria, and pseudobulbar affect. Furthermore, the association between affective symptoms and quality of life and the currently used diagnostic instruments for assessing these symptoms are considered whereby relevant studies published between 2009 and 2021 were included in the review. RESULTS: Patients with mild and moderate disability more frequently reported severe problems with depression and anxiety than severe mobility problems. Apart from the occurrence of depression, little is known about the association of other affective symptoms such as anxiety, bipolar disorder, euphoria, and pseudobulbar affect and subsyndromal symptoms, which fail to meet the diagnostic criteria but are nevertheless a significant source of distress. Although there are a few recommendations in the research to perform routine screenings for diagnosable affective disorders, a standardized diagnostic procedure to assess subsyndromal symptoms is still lacking. As the applied measurements are diverse and show low accuracy to detect these symptoms, patients who experience affective symptoms are less likely to be identified. DISCUSSION: In addition to the consideration of definite psychiatric diagnoses, there is an unmet need for a common definition and assessment of disease-related affective symptoms in MS. Future studies should focus on the improvement and standardization of a common diagnostic procedure for subsyndromal affective symptoms in MS to enable integrated and optimal care for patients. Springer Berlin Heidelberg 2022-09-21 2023 /pmc/articles/PMC9813146/ /pubmed/36129540 http://dx.doi.org/10.1007/s00415-022-11359-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Filser, Melanie Buchner, Axel Fink, Gereon Rudolf Gold, Stefan M. Penner, Iris-Katharina The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools |
title | The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools |
title_full | The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools |
title_fullStr | The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools |
title_full_unstemmed | The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools |
title_short | The manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools |
title_sort | manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813146/ https://www.ncbi.nlm.nih.gov/pubmed/36129540 http://dx.doi.org/10.1007/s00415-022-11359-6 |
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