Cargando…

Amniotic stem cells as a source of regenerative medicine to treat female infertility

Impaired reproductive health is a worldwide problem that affects the psychological well-being of a society. Despite the technological developments to treat infertility, the global infertility rate is increasing significantly. Many infertility conditions are currently treated using various advanced c...

Descripción completa

Detalles Bibliográficos
Autores principales: Naeem, Aisha, Gupta, Nikita, Naeem, Usra, Elrayess, Mohamed A., Albanese, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813167/
https://www.ncbi.nlm.nih.gov/pubmed/36251241
http://dx.doi.org/10.1007/s13577-022-00795-1
_version_ 1784863874377318400
author Naeem, Aisha
Gupta, Nikita
Naeem, Usra
Elrayess, Mohamed A.
Albanese, Chris
author_facet Naeem, Aisha
Gupta, Nikita
Naeem, Usra
Elrayess, Mohamed A.
Albanese, Chris
author_sort Naeem, Aisha
collection PubMed
description Impaired reproductive health is a worldwide problem that affects the psychological well-being of a society. Despite the technological developments to treat infertility, the global infertility rate is increasing significantly. Many infertility conditions are currently treated using various advanced clinical approaches such as intrauterine semination (IUI), in vitro fertilization (IVF), and intracytoplasmic injection (ICSI). Nonetheless, clinical management of some conditions such as dysfunctional endometrium, premature ovarian failure, and ovarian physiological aging still pose significant challenges. Stem cells based therapeutic strategies have a long-standing history to treat many infertility conditions, but ethical restrictions do not allow the broad-scale utilization of adult mesenchymal stromal/stem cells (MSCs). Easily accessible, placental derived or amniotic stem cells present an invaluable alternative source of non-immunogenic and non-tumorigenic stem cells that possess multilineage potential. Given these characteristics, placental or amniotic stem cells (ASCs) have been investigated for therapeutic purposes to address infertility in the last decade. This study aims to summarize the current standing and progress of human amniotic epithelial stem cells (hAECs), amniotic mesenchymal stem cells (hAMSCs), and amniotic fluid stem cells (hAFSCs) in the field of reproductive medicine. The therapeutic potential of these cells to restore or enhance normal ovarian function and pregnancy outcomes are highlighted in this study.
format Online
Article
Text
id pubmed-9813167
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Nature Singapore
record_format MEDLINE/PubMed
spelling pubmed-98131672023-01-06 Amniotic stem cells as a source of regenerative medicine to treat female infertility Naeem, Aisha Gupta, Nikita Naeem, Usra Elrayess, Mohamed A. Albanese, Chris Hum Cell Review Article Impaired reproductive health is a worldwide problem that affects the psychological well-being of a society. Despite the technological developments to treat infertility, the global infertility rate is increasing significantly. Many infertility conditions are currently treated using various advanced clinical approaches such as intrauterine semination (IUI), in vitro fertilization (IVF), and intracytoplasmic injection (ICSI). Nonetheless, clinical management of some conditions such as dysfunctional endometrium, premature ovarian failure, and ovarian physiological aging still pose significant challenges. Stem cells based therapeutic strategies have a long-standing history to treat many infertility conditions, but ethical restrictions do not allow the broad-scale utilization of adult mesenchymal stromal/stem cells (MSCs). Easily accessible, placental derived or amniotic stem cells present an invaluable alternative source of non-immunogenic and non-tumorigenic stem cells that possess multilineage potential. Given these characteristics, placental or amniotic stem cells (ASCs) have been investigated for therapeutic purposes to address infertility in the last decade. This study aims to summarize the current standing and progress of human amniotic epithelial stem cells (hAECs), amniotic mesenchymal stem cells (hAMSCs), and amniotic fluid stem cells (hAFSCs) in the field of reproductive medicine. The therapeutic potential of these cells to restore or enhance normal ovarian function and pregnancy outcomes are highlighted in this study. Springer Nature Singapore 2022-10-17 2023 /pmc/articles/PMC9813167/ /pubmed/36251241 http://dx.doi.org/10.1007/s13577-022-00795-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Naeem, Aisha
Gupta, Nikita
Naeem, Usra
Elrayess, Mohamed A.
Albanese, Chris
Amniotic stem cells as a source of regenerative medicine to treat female infertility
title Amniotic stem cells as a source of regenerative medicine to treat female infertility
title_full Amniotic stem cells as a source of regenerative medicine to treat female infertility
title_fullStr Amniotic stem cells as a source of regenerative medicine to treat female infertility
title_full_unstemmed Amniotic stem cells as a source of regenerative medicine to treat female infertility
title_short Amniotic stem cells as a source of regenerative medicine to treat female infertility
title_sort amniotic stem cells as a source of regenerative medicine to treat female infertility
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813167/
https://www.ncbi.nlm.nih.gov/pubmed/36251241
http://dx.doi.org/10.1007/s13577-022-00795-1
work_keys_str_mv AT naeemaisha amnioticstemcellsasasourceofregenerativemedicinetotreatfemaleinfertility
AT guptanikita amnioticstemcellsasasourceofregenerativemedicinetotreatfemaleinfertility
AT naeemusra amnioticstemcellsasasourceofregenerativemedicinetotreatfemaleinfertility
AT elrayessmohameda amnioticstemcellsasasourceofregenerativemedicinetotreatfemaleinfertility
AT albanesechris amnioticstemcellsasasourceofregenerativemedicinetotreatfemaleinfertility