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Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review

Transcranial magnetic stimulation (TMS) is a non-invasive technique that can transiently interfere with local cortical functioning, thus enabling inferences of causal left AG involvement in higher functions from experimentation with healthy participants. Here, we examine 35 studies that measure beha...

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Autores principales: Wagner, Jennifer, Rusconi, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813212/
https://www.ncbi.nlm.nih.gov/pubmed/36260126
http://dx.doi.org/10.1007/s00429-022-02576-w
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author Wagner, Jennifer
Rusconi, Elena
author_facet Wagner, Jennifer
Rusconi, Elena
author_sort Wagner, Jennifer
collection PubMed
description Transcranial magnetic stimulation (TMS) is a non-invasive technique that can transiently interfere with local cortical functioning, thus enabling inferences of causal left AG involvement in higher functions from experimentation with healthy participants. Here, we examine 35 studies that measure behavioural outcomes soon after or during targeting TMS to the left AG, by design and as documented by individual magnetic resonance images, in healthy adult participants. The reviewed evidence suggests a specific causal involvement of the left AG in a wide range of tasks involving language, memory, number processing, visuospatial attention, body awareness and motor planning functions. These core findings are particularly valuable to inform theoretical models of the left AG role(s) in higher functions, due to the anatomical specificity afforded by the selected studies and the complementarity of TMS to different methods of investigation. In particular, the variety of the operations within and between functions in which the left AG appears to be causally involved poses a formidable challenge to any attempts to identify a single computational process subserved by the left AG (as opposed to just outlining a broad type of functional contribution) that could apply across thematic areas. We conclude by highlighting directions for improvement in future experimentation with TMS, in order to strengthen the available evidence, while taking into account the anatomical heterogeneity of this brain region. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02576-w.
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spelling pubmed-98132122023-01-06 Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review Wagner, Jennifer Rusconi, Elena Brain Struct Funct Review Transcranial magnetic stimulation (TMS) is a non-invasive technique that can transiently interfere with local cortical functioning, thus enabling inferences of causal left AG involvement in higher functions from experimentation with healthy participants. Here, we examine 35 studies that measure behavioural outcomes soon after or during targeting TMS to the left AG, by design and as documented by individual magnetic resonance images, in healthy adult participants. The reviewed evidence suggests a specific causal involvement of the left AG in a wide range of tasks involving language, memory, number processing, visuospatial attention, body awareness and motor planning functions. These core findings are particularly valuable to inform theoretical models of the left AG role(s) in higher functions, due to the anatomical specificity afforded by the selected studies and the complementarity of TMS to different methods of investigation. In particular, the variety of the operations within and between functions in which the left AG appears to be causally involved poses a formidable challenge to any attempts to identify a single computational process subserved by the left AG (as opposed to just outlining a broad type of functional contribution) that could apply across thematic areas. We conclude by highlighting directions for improvement in future experimentation with TMS, in order to strengthen the available evidence, while taking into account the anatomical heterogeneity of this brain region. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02576-w. Springer Berlin Heidelberg 2022-10-19 2023 /pmc/articles/PMC9813212/ /pubmed/36260126 http://dx.doi.org/10.1007/s00429-022-02576-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Wagner, Jennifer
Rusconi, Elena
Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
title Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
title_full Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
title_fullStr Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
title_full_unstemmed Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
title_short Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
title_sort causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813212/
https://www.ncbi.nlm.nih.gov/pubmed/36260126
http://dx.doi.org/10.1007/s00429-022-02576-w
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