IκB(NS)-deficiency protects mice from fatal Listeria monocytogenes infection by blunting pro-inflammatory signature in Ly6C(high) monocytes and preventing exaggerated innate immune responses

IκB proteins regulate the inhibition and activation of NF-κB transcription factor complexes. While classical IκB proteins keep NF-κB complexes inactive in the cytoplasm, atypical IκB proteins act on activated NF-κB complexes located in the nucleus. Most of the knowledge regarding the function of IκB...

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Detalles Bibliográficos
Autores principales: Frentzel, Sarah, Jeron, Andreas, Pausder, Alexander, Kershaw, Olivia, Volckmar, Julia, Schmitz, Ingo, Bruder, Dunja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813228/
https://www.ncbi.nlm.nih.gov/pubmed/36618344
http://dx.doi.org/10.3389/fimmu.2022.1028789

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