Cargando…

Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism

Transmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular function for TMEM135 in lipid metabolism has been identified. In this study, we performed a lipid analysis of tissues from Tmem135 mutant mice and found s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Landowski, Michael, Bhute, Vijesh J., Grindel, Samuel, Haugstad, Zachary, Gyening, Yeboah K., Tytanic, Madison, Brush, Richard S., Moyer, Lucas J., Nelson, David W., Davis, Christopher R., Yen, Chi-Liang Eric, Ikeda, Sakae, Agbaga, Martin-Paul, Ikeda, Akihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813353/ https://www.ncbi.nlm.nih.gov/pubmed/36599953 http://dx.doi.org/10.1038/s42003-022-04404-7

Ejemplares similares

A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
por: Landowski, Michael, et al.
Publicado: (2022)

ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis
por: Gyening, Yeboah Kofi, et al.
Publicado: (2022)

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4
por: Yeboah, Gyening Kofi, et al.
Publicado: (2021)

Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice
por: Landowski, Michael, et al.
Publicado: (2020)

TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis
por: Hu, Donghua, et al.
Publicado: (2023)

A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
por: Gyening, Yeboah Kofi, et al.
Publicado: (2023)

Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis
por: Zyla-Jackson, Katarzyna, et al.
Publicado: (2023)

The effect of Tmem135 overexpression on the mouse heart
por: Lewis, Sarah Aileen, et al.
Publicado: (2018)

Persistent Vulvar Itch Unresponsive to Treatment: A Case of Vulvar Schistosomiasis Caused by Schistosoma mansoni and a Brief Review of Literature
por: Gyening-Yeboah, Anthony, et al.
Publicado: (2023)

Redox regulated peroxisome homeostasis
por: Wang, Xiaofeng, et al.
Publicado: (2014)

Glutathione and peroxisome redox homeostasis
por: Ferreira, Maria J., et al.
Publicado: (2023)

DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency
por: Swinkels, Daniëlle, et al.
Publicado: (2023)

(1)H Nuclear magnetic resonance based targeted profiling of metabolic responses induced by DNA damaging agents and PARP inhibition in MCF-7 cells
por: Bhute, Vijesh, et al.
Publicado: (2014)

BK virus infection and outcome following kidney transplantation in childhood
por: McCaffrey, James, et al.
Publicado: (2021)

Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
por: Bhute, Vijesh J., et al.
Publicado: (2017)

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis
por: Hua, Rong, et al.
Publicado: (2017)

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies
por: Lee, Wei-Hua, et al.
Publicado: (2016)

Peroxisomal regulation of redox homeostasis and adipocyte metabolism
por: Liu, Jingjing, et al.
Publicado: (2019)

Defects in Actin Dynamics Lead to an Autoinflammatory Condition through the Upregulation of CXCL5
por: Verdoni, Angela M., et al.
Publicado: (2008)

The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
por: Bhute, Vijesh J., et al.
Publicado: (2016)

Association of genetic variants of TMEM135 and PEX5 in the peroxisome pathway with cutaneous melanoma-specific survival
por: Wang, Haijiao, et al.
Publicado: (2021)

Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis
por: Yurimoto, Hiroya, et al.
Publicado: (2011)

Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart
por: Hou, Lianguo, et al.
Publicado: (2012)

DHA does not protect ELOVL4 transgenic mice from retinal degeneration
por: Li, Feng, et al.
Publicado: (2009)

Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice
por: Pauter, Anna M., et al.
Publicado: (2014)

A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached
por: Luxwolda, Martine F., et al.
Publicado: (2011)

Comparative analyses of DHA-Phosphatidylcholine and recombination of DHA-Triglyceride with Egg-Phosphatidylcholine or Glycerylphosphorylcholine on DHA repletion in n-3 deficient mice
por: Wu, Fang, et al.
Publicado: (2017)

Cleavage of transmembrane junction proteins and their role in regulating epithelial homeostasis
por: Nava, Porfirio, et al.
Publicado: (2013)

Inhibitory Mechanisms of DHA/CQ on pH and Iron Homeostasis of Erythrocytic Stage Growth of Plasmodium falciparum
por: Tang, Tian, et al.
Publicado: (2019)

Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity
por: Logan, Sreemathi, et al.
Publicado: (2014)

Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse
por: Schori, Christian, et al.
Publicado: (2018)

The Efficacy of MAG-DHA for Correcting AA/DHA Imbalance of Cystic Fibrosis Patients
por: Morin, Caroline, et al.
Publicado: (2018)

Efficient Enrichment of Retinal DHA with Dietary Lysophosphatidylcholine-DHA: Potential Application for Retinopathies
por: Sugasini, Dhavamani, et al.
Publicado: (2020)

Dynamics of Peroxisome Homeostasis and Its Role in Stress Response and Signaling in Plants
por: Su, Tong, et al.
Publicado: (2019)

Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2()
por: Lee, Yoon Kwang, et al.
Publicado: (2018)

Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging
por: Kim, Jinoh, et al.
Publicado: (2022)

Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders
por: Kleiboeker, Brian, et al.
Publicado: (2022)

Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background
por: Kawakami-Schulz, Sharolyn V., et al.
Publicado: (2012)

Human pluripotent stem cell‐derived epicardial progenitors can differentiate to endocardial‐like endothelial cells
por: Bao, Xiaoping, et al.
Publicado: (2017)

In Vivo Digestion of Egg Products Enriched with DHA: Effect of the Food Matrix on DHA Bioavailability
por: Pineda-Vadillo, Carlos, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4puddtipqa7eiuo4dl5rmmmq4d