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Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis

OBJECTIVES: Brucellosis is one of the most prevalent zoonotic diseases common between humans and animals. Despite eradication efforts, the burden of the disease is well-known in endemic countries and in countries where brucellosis has not been an important health issue until recently. The aim of thi...

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Autores principales: Khoshnood, Saeed, Pakzad, Reza, Koupaei, Maryam, Shirani, Maryam, Araghi, Almas, Irani, Golnaz Mokhtari, Moradi, Melika, Pakzad, Iraj, Sadeghifard, Nourkhoda, Heidary, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813401/
https://www.ncbi.nlm.nih.gov/pubmed/36619963
http://dx.doi.org/10.3389/fvets.2022.976215
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author Khoshnood, Saeed
Pakzad, Reza
Koupaei, Maryam
Shirani, Maryam
Araghi, Almas
Irani, Golnaz Mokhtari
Moradi, Melika
Pakzad, Iraj
Sadeghifard, Nourkhoda
Heidary, Mohsen
author_facet Khoshnood, Saeed
Pakzad, Reza
Koupaei, Maryam
Shirani, Maryam
Araghi, Almas
Irani, Golnaz Mokhtari
Moradi, Melika
Pakzad, Iraj
Sadeghifard, Nourkhoda
Heidary, Mohsen
author_sort Khoshnood, Saeed
collection PubMed
description OBJECTIVES: Brucellosis is one of the most prevalent zoonotic diseases common between humans and animals. Despite eradication efforts, the burden of the disease is well-known in endemic countries and in countries where brucellosis has not been an important health issue until recently. The aim of this study was to evaluate the prevalence, diagnosis, and manifestations of brucellosis. METHODS: In this study, PubMed, Web of Science, Scopus, Embase, and Google scholar databases were systematically searched to find studies published from 2011 to 2021. The search was conducted using text words and Medical Subject Headings (MeSH) Terms on the prevalence of brucellosis. Stata software 14.0 was used for all analyses. RESULTS: Based on the results, the pooled prevalence of brucellosis was 15.27% (95% CI: 9.68–21.86; heterogeneity I(2) index: 97.43; p < 0.001) for man and 15.33% (95% CI: 7.19–25.75; heterogeneity I(2) index: 98.19; p < 0.001) for woman. Age (coefficient: 0.240; p = 0.480), gender (coefficient: −0.017; p = 0.800), and publication year (coefficient: 0.114; p = 0.861) showed no significant effect on heterogeneity among studies. Egger's test indicated a significant publication bias for the prevalence of brucellosis (coefficient 3.894; p < 0.001). Moreover, the trim-and-fill method exhibited that the adjusted prevalence of brucellosis (18.30%, 95% CI: 14.10–22.52) was not significantly different from the original prevalence of brucellosis. CONCLUSION: The pooled estimate for brucellosis prevalence was estimated as 15.53%. To better understand the epidemiology of brucellosis globally, more extensive studies are needed to be conducted throughout the world, especially in developing and low-income countries.
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spelling pubmed-98134012023-01-06 Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis Khoshnood, Saeed Pakzad, Reza Koupaei, Maryam Shirani, Maryam Araghi, Almas Irani, Golnaz Mokhtari Moradi, Melika Pakzad, Iraj Sadeghifard, Nourkhoda Heidary, Mohsen Front Vet Sci Veterinary Science OBJECTIVES: Brucellosis is one of the most prevalent zoonotic diseases common between humans and animals. Despite eradication efforts, the burden of the disease is well-known in endemic countries and in countries where brucellosis has not been an important health issue until recently. The aim of this study was to evaluate the prevalence, diagnosis, and manifestations of brucellosis. METHODS: In this study, PubMed, Web of Science, Scopus, Embase, and Google scholar databases were systematically searched to find studies published from 2011 to 2021. The search was conducted using text words and Medical Subject Headings (MeSH) Terms on the prevalence of brucellosis. Stata software 14.0 was used for all analyses. RESULTS: Based on the results, the pooled prevalence of brucellosis was 15.27% (95% CI: 9.68–21.86; heterogeneity I(2) index: 97.43; p < 0.001) for man and 15.33% (95% CI: 7.19–25.75; heterogeneity I(2) index: 98.19; p < 0.001) for woman. Age (coefficient: 0.240; p = 0.480), gender (coefficient: −0.017; p = 0.800), and publication year (coefficient: 0.114; p = 0.861) showed no significant effect on heterogeneity among studies. Egger's test indicated a significant publication bias for the prevalence of brucellosis (coefficient 3.894; p < 0.001). Moreover, the trim-and-fill method exhibited that the adjusted prevalence of brucellosis (18.30%, 95% CI: 14.10–22.52) was not significantly different from the original prevalence of brucellosis. CONCLUSION: The pooled estimate for brucellosis prevalence was estimated as 15.53%. To better understand the epidemiology of brucellosis globally, more extensive studies are needed to be conducted throughout the world, especially in developing and low-income countries. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9813401/ /pubmed/36619963 http://dx.doi.org/10.3389/fvets.2022.976215 Text en Copyright © 2022 Khoshnood, Pakzad, Koupaei, Shirani, Araghi, Irani, Moradi, Pakzad, Sadeghifard and Heidary. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Khoshnood, Saeed
Pakzad, Reza
Koupaei, Maryam
Shirani, Maryam
Araghi, Almas
Irani, Golnaz Mokhtari
Moradi, Melika
Pakzad, Iraj
Sadeghifard, Nourkhoda
Heidary, Mohsen
Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis
title Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis
title_full Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis
title_fullStr Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis
title_full_unstemmed Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis
title_short Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis
title_sort prevalence, diagnosis, and manifestations of brucellosis: a systematic review and meta-analysis
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813401/
https://www.ncbi.nlm.nih.gov/pubmed/36619963
http://dx.doi.org/10.3389/fvets.2022.976215
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